Débora Botéquio Moretti

• Abstract

  Nanobodies (Nbs or VHHs) have great therapeutic potential and have been studied as a treatment for numerous diseases. In addition to being more cost-effective to produce, these camelid-derived single-domain antibody fragments are small, stable, soluble in aqueous solutions, and have high specificity and affinity for the target antigen. Furthermore, VHHs exhibit low toxicity and immunogeni…

  Phage-display panning to screen neutralizing anti-scorpionic and anti-TIM-3 VHHs, AV.EXT

• Abstract

  Accidents with venomous animals are considered a public health problem in several countries, mainly tropical and subtropical. In Brazil, more than half of these accidents result from scorpion bites, which were responsible for 31% of deaths caused by this type of incident in 2018. Severe and moderate cases of scorpion envenomation are treated with specific serotherapy, which has been produ…

  Nanobodies as an alternative therapy for passive immunization, AP.R

• Abstract

  Among the components of bovine colostrum, the high presence of antioxidants factors is crucial to the health of the newborn, collaborating with overcoming oxidative stress after birth. In intensive fish farming, the stress due to common management practices results in lower reproductive performance and increased susceptibility to diseases. One of the main consequences of stress is the cha…

  Antioxidants factors of bovine colostrum in cellular protection, AP.JP

• Abstract

  Accidents with venomous animals are a public health problem in several countries, mainly tropical and subtropical. In Brazil, more than half of accidents occur due to scorpion stings and, in 2018 alone, 157,069 accidents and 85 deaths were recorded, corresponding to 31% of deaths from accidents with venomous animals. Severe and moderate cases of scorpion envenomation should be treated wit…

  Evaluation of the immunotherapeutic potential of nanobodies against scorpion toxins, BP.MS

• Abstract

  Intestinal barrier consists of a monolayer of cells responsible for protection, digestion and absorption of molecules, and secretion of hormones and enzymes. These physiological processes are under the neuro-hormonal control and are therefore likely to be influenced by external stimuli. Adverse conditions determine increased absorption of proteins, both via transcellular and paracellular,…

  Antioxidant protection of bovine colostrum on intestinal cells of juvenile pacu (Piaractus mesopotamicus) undergoing stress, BP.MS

• Abstract

  In addition to being a rich source of nutrients for newborn mammals, colostrum has important immune factors that are important for overcoming challenges in the first weeks of life. The quality of colostrum depends on some factors such as age, race and number of pregnancies. High concentrations of immunoglobulin G (IgG) determine, normally, a high quality colostrum. However, the relationsh…

  Holstein-Jersey crossbred colostrum proteins x Jersey primiparous and multiparous cows, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Nanobodies (Nbs or VHHs) have great therapeutic potential and have been studied as a treatment for numerous diseases. In addition to having greater economic efficiency of production, these camelid-derived single-domain antibody fragments are small, stable, soluble in aqueous solutions, and have high specificity and affinity for the target antigen. In addition, VHHs exhibit low toxicity a…

  Construction of VHH library derived from camelids, BE.EP.MS

• Abstract

  Colostrum has important biological molecules, such as immunoglobulin, that aid the newborn to overcome challenges in the first weeks of life. Growth factors are known to increase the proliferation and intestinal cell differentiation and the antimicrobial factors are responsible for inhibiting the bacterial activity and growth. The antioxidants components of colostrum prevent oxidative cel…

  Effect of bovine colostrum in the expression of NFkB, BE.EP.MS