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Effect of bovine colostrum in the expression of NFkB

Grant number: 17/02915-7
Support type:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): March 31, 2017
Effective date (End): May 30, 2017
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Production
Principal researcher:Débora Botéquio Moretti
Grantee:Mariana Caroline Furian Pontin
Supervisor abroad: Ouliana Ziouzenkova
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Research place: Ohio State University, Columbus, United States  
Associated to the scholarship:15/16151-3 - Antioxidant protection of bovine colostrum on intestinal cells of juvenile pacu (Piaractus mesopotamicus) undergoing stress, BP.MS


Colostrum has important biological molecules, such as immunoglobulin, that aid the newborn to overcome challenges in the first weeks of life. Growth factors are known to increase the proliferation and intestinal cell differentiation and the antimicrobial factors are responsible for inhibiting the bacterial activity and growth. The antioxidants components of colostrum prevent oxidative cell damage caused by free radicals thereby protecting and improving the calf's development. Immunoglobulins, lactoferrin, lactoperoxidase, lysozyme, and antioxidants confers antibacterial and anti-inflammatory properties of colostrum, since oxidative stress and microbial infections play a major role in inflammation-induced diseases. Colostrum composition varied between animals, and depend on nutrition and other environmental factors. Here we propose to develop an assay for cumulative assessment of colostrum properties as antioxidant, anti-inflammatory agent and energy source. We will develop this assay using biosensor cell lines that were previously developed in the hosting Dr. Ziouzenkova's laboratory. These cells are stably transfected with gene constructs that "report" anti-inflammatory, anti-oxidative, and anti-obesogenic properties of diverse classes of compounds from foods. Various concentrations of colostrum will be tested and compared with known agonists and antagonists of such reporter activities. These in vitro assay will provide cumulative assessment for colostrum biomedical properties. We will also utilize nanoscaffold to improve colostrum absorption. The successful execution of this project will provide a new means of testing biomedical quality of natural foods in diverse environments. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEE, AEJIN; PONTIN, MARIANA C. F.; KOSMERL, ERICA; JIMENEZ-FLORES, RAFAEL; MORETTI, DEBORA B.; ZIOUZENKOVA, OULIANA. Assessment of adipogenic, antioxidant, and anti-inflammatory properties of whole and whey bovine colostrum. JOURNAL OF DAIRY SCIENCE, v. 102, n. 10, p. 8614-8621, OCT 2019. Web of Science Citations: 0.

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