CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Otávio Cabral-Marques is a Professor of Molecular Medicine at the Faculty of Medicine, University of São Paulo (FM-USP), in the Department of Internal Medicine, where he also serves as the representative for the Assistant Professor category on the Department's Council. He is a researcher at IDOR. His work involves integrative systems analysis of neuroimmune networks to understand immune responses and novel molecular mechanisms in depression, infections, autoimmune diseases, and cancer.Previously, he held the position of Visiting Professor in the Department of Pharmacy at the Health Sciences Center, Federal University of Rio Grande do Norte, from August 29, 2022, to April 10, 2023. Currently, he serves as a Full Advisor in the Departments of Internal Medicine, Immunology, and the Faculty of Pharmaceutical Sciences (FCF/USP), as well as a Guest Advisor in the Interunit Graduate Program in Bioinformatics at the University of São Paulo (USP).He holds degrees in Biology and Psychology, earned his Master's (20062008) and Ph.D. (20082012) in Immunology at the Institute of Biomedical Sciences, USP, and completed a sandwich doctorate at the University of Washington School of Medicine and Seattle Children's Research Institute, Seattle, WA, USA, from December 2010 to May 2011. He also undertook postdoctoral studies in Brazil (University of São Paulo; 20122015) and Germany (Department of Rheumatology and Clinical Immunology, University of Lubeck: October 2015 to April 2019; and the Center for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg: April 2015 to November 2019).Additionally, he serves as the Junior Ambassador of Brazil in the Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), part of the Universal Scientific Education and Research Network (USERN). He can be contacted via email at otavio.cmarques@gmail.com. (Source: Lattes Curriculum)
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Outbreaks of arboviruses such as Zika e Dengue in the Americas have led to a state of international public emergency. The viruses are transmitted by the same vector mosquito (Aedes aegypti), have co-circulated throughout the world, and trigger common clinical features. Despite the global health problems caused by these etiological agents, there is a scarce knowledge about the systemic imm…
The current pandemic of the Coronavirus respiratory disease 2019 (COVID-19) represents a state of international public emergency. The virus causing the disease is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been circulating throughout the world, triggering clinical manifestations ranging from asymptomatic cases to severe acute respiratory syndrome and death…
Viral hepatitis A, B, C, D, and E (respectively, VHA, VHB, VHC, VHD, and VHE) constitute a group of viruses that present significant differences in terms of physiopathology, taxonomy, biological cycle, structure, and genetics. However, all of them result in similar pathologies, such as jaundice, liver lesions, fatigue, dizziness, nausea, vomiting, fever, abdominal pain, dark urine, and pa…
Autoantibodies (AAbs) are antibodies which react with self-molecules (autoantigens). Molecules whose own existence and functionality were once contested, have now been accepted in the context of autoimmune diseases. Although considered mainly pathological, these are ubiquitously present molecules which contribute to homeostasis. One particular class of are the functional AAbs, which can b…
The Coronavirus Disease 2019 (COVID-19) pandemic has left many psychopathological implications in COVID-19 survivors, such as depression, anxiety and cognitive impairments, which are now recognized as primary symptoms of "post-acute COVID-19 syndrome"11 . Depressive psychopathology has already been reported in about 35% of patients in short, medium and long-term follow-up after infection …
Viruses are estimated to cause between 15% and 20% of all reported cancer cases. There areseven known human oncoviruses: Epstein-Barr Virus (EBV), Hepatitis B Virus (HBV), HumanPapillomavirus (HPV), Human T-Cell Leukemia Virus Type 1 (HTLV-1), Hepatitis C Virus(HCV ), Human Herpesvirus 8 (KSHV) and Merkel Cell Polyomavirus (MCV). These virusescan lead to uncontrolled cell growth and the d…
Viral infections affecting the Central Nervous System (CNS) represent an emergent cause of illness and mortality in Brazil and worldwide. The emergence, re-emergence, and dysfunctions associated with neuroglial infections by viruses with neurotropic properties, such as ZIKV and DENV flaviviruses, SARS-CoV-2 and Rabies Virus (RABV), justify the need to understand the commonality and differ…
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We recently showed that older patients with severe COVID-19 have high levels of autoantibodies (aab) against molecules targeting Cardiolipin and Platelet glycoprotein compared to healthy controls. In this case, we found that, in particular, anti-cardiolipin1 and anti-platelet antibodies increase the risk of thrombosis-related events such as pulmonary thromboembolism and deep vein thrombos…
The immune system plays an important role in the homeostatic control of the body. For this fundamental function, the system is activated in response to external or internal injuries. Therefore, the activation mechanisms of the immune system are important and desirable but must be finely controlled to avoid immunopathology. Several evolutionary conserved immunoregulatory mechanisms such as…
Dengue disease is a global health problem that affects approximately 390 million people per year, in over 120 countries but no specific therapy or vaccine is currently available to effectively combat dengue virus (DENV) infection. While most of the individuals infected by DENV are asymptomatic or present uncomplicated symptoms, 5-20% of the patients develop severe dengue (SD) in several d…
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