João Agostinho Machado Neto
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Has bachelor's degree in Biology (CEUSNP, 2009), Master's degree in Internal Medicine (Unicamp, 2011), PhD in Sciences with focus in Internal Medicine (Unicamp, 2015) and Postdoctoral in Internal Medicine (FMRP - USP-RP, 2015-2017). He is currently Assistant Professor at the Department of Pharmacology of the Institute of Biomedical Sciences of the University of São Paulo (ICB - USP) and develops research focused on the identification and characterization of antineoplastics and on the investigation of expression, activation and function of genes involved in signaling pathways cell alterations in cancer, especially hematological malignancies. (Source: Lattes Curriculum)
- Comprehensive analysis of genomic data for identification and validation of novel therapeutic targets involved in cellular cytoskeleton regulation in acute leukemia, AP.R
Abstract
Acute leukemias are aggressive hematological malignancies characterized by clonal proliferation with replacement and accumulation of neoplastic cells in the bone marrow, peripheral blood and other organs that suppress normal hematopoiesis. Despite the great advances in understanding the complexity involved in the molecular changes of acute leukemia in recent years, very little has been ...
- Investigation of Stathmin 1 and microtubule instability in phenotype of hematological neoplasms, AP.R
Abstract
Acute leukemias comprise a group of hematological malignancies characterized by the expansion of blasts in bone marrow and peripheral blood, which is mainly due to the loss of differentiation ability of stem cells to functional cells in terminal stage, deregulation of proliferation and resistance to apoptosis. The mortality of adult patients with acute leukemia is very high, making it i...
- Cellular and molecular evaluation of ANKHD1 silencing in breast cancer, BP.IC
Abstract
Although widely studied, the molecular basis of breast cancer is still unclear, and the relevance of identifying new molecular markers and signaling pathways that may be useful in prognostic stratification, predicting response to therapy, and developing breast cancer new therapeutic options is evident. In this sense, the Ankyrin Repeat and KH Domain Containing 1 protein, ANKHD1, has bee...
- Investigation of the cellular and molecular effects of reversine in glioma models, BP.IC
Abstract
Gliomas belong to a heterogeneous group of brain tumors with distinct biological and clinical properties that include molecular complexity, as well as inconsistencies in histopathological classification, resulting in an inaccurate prediction of disease progression and failure to use standard therapy. A challenge for the treatment of gliomas is the high recurrence rates. Despite the grea...
- Investigation of the effect of potential Stathmin 1 inhibitors obtained by chemoinformatics on the phenotype of acute leukemias, BP.MS
Abstract
Acute leukemias are aggressive neoplasias characterized by clonal proliferation with replacement and accumulation of neoplastic blasts in bone marrow or peripheral blood. Despite great advances in understanding the complexity behind the molecular changes in acute leukemia in recent years, very little has been translated into new therapies. Stathmin 1 is a microtubule destabilizing prote...
(Only some records are available in English at this moment)
- Investigation of IRS2 protein function in hematopoietic cells, BP.PD
Abstract
The insulin receptor substrate (IRS) comprise a family of cytoplasmic adapter proteins that recruit effector proteins involved in cellular signaling pathways, including PI3K/Akt, MAP kinase and JAK/STAT, and were initially characterized in insulin signaling. The insulin receptor substrate 2 (IRS2) may also be activated through its association with three growth factors receptors importan...
- Study of ANKHD1 function on the proliferation, apoptosis and cell cycle in hematological neoplasia, BP.DR
- A study of the IRS1 function and expression in acute leukemias and myelodysplasias, BP.MS
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 4 / 4 | Completed scholarships in Brazil |
| 10 / 10 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 10 |
| Citations | 20 |
| Cit./Article | 2.0 |
| Data from Web of Science | |
MACHADO-NETO, JOAO AGOSTINHO; LAZARINI, MARIANA; FAVARO, PATRICIA; CAMPOS, PAULA DE MELO; SCOPIM-RIBEIRO, RENATA; FRANCHI JUNIOR, GILBERTO CARLOS; NOWILL, ALEXANDRE EDUARDO; MOURA LIMA, PAULO ROBERTO; COSTA, FERNANDO FERREIRA; BENICHOU, SERGE; et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1853, n. 3, p. 583-593, MAR 2015. Web of Science Citations: 10. (09/00268-8, 12/09982-8, 11/06840-5, 11/51959-0)
PASSAIA, BARBARA DOS SANTOS; LIMA, KELI; KREMER, JEAN LUCAS; DA CONCEICAO, BARBARA BRITO; DE PAULA MARIANI, BEATRIZ MARINHO; LIPRERI DA SILVA, JEAN CARLOS; NOGUEIRA ZERBINI, MARIA CLAUDIA; BARISSON VILLARES FRAGOSO, MARIA CANDIDA; MACHADO-NETO, JOAO AGOSTINHO; PACICCO LOTFI, CLAUDIMARA FERINI. Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours. INVESTIGATIONAL NEW DRUGS, v. 38, n. 3, p. 899-908, JUN 2020. Web of Science Citations: 0. (16/17285-6, 17/24993-0, 16/12381-7)
LIMA, KELI; ELIAS GODOY CARLOS, JORGE ANTONIO; ALVES-PAIVA, RAQUEL DE MELO; VICARI, HUGO PASSOS; DE SOUZA SANTOS, FABIO PIRES; HAMERSCHLAK, NELSON; COSTA-LOTUFO, LETICIA VERAS; TRAINA, FABIOLA; MACHADO-NETO, JOAO AGOSTINHO. Reversine exhibits antineoplastic activity in JAK2(V)(617)(F)-positive myeloproliferative neoplasms. SCIENTIFIC REPORTS, v. 9, JUL 9 2019. Web of Science Citations: 0. (17/24993-0)
ELIAS GODOY CARLOS, JORGE ANTONIO; LIMA, KELI; COELHO-SILVA, JUAN LUIZ; ALVES-PAIVA, RAQUEL DE MELO; MORENO, NATALIA CESTARI; VICARI, HUGO PASSOS; DE SOUZA SANTOS, FABIO PIRES; HAMERSCHLAK, NELSON; COSTA-LOTUFO, LETICIA VERAS; TRAINA, FABIOLA; et al. Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia. CELLULAR ONCOLOGY, AUG 2020. Web of Science Citations: 0. (17/24993-0, 18/19372-9, 15/17177-6)
MACHADO-NETO, JOAO AGOSTINHO; CAMPOS, PAULA DE MELO; FAVARO, PATRICIA; LAZARINI, MARIANA; SANTOS DUARTE, ADRIANA DA SILVA; LORAND-METZE, IRENE; COSTA, FERNANDO FERREIRA; OLALLA SAAD, SARA TERESINHA; TRAINA, FABIOLA. Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2(V617F) cells. ONCOTARGET, v. 6, n. 30, p. 29573-29584, OCT 6 2015. Web of Science Citations: 7. (12/09982-8, 11/51959-0, 14/23092-0, 11/06840-5)
MACHADO-NETO, JOAO AGOSTINHO; FENERICH, BRUNA ALVES; SCOPIM-RIBEIRO, RENATA; EIDE, CHRISTOPHER A.; COELHO-SILVA, JUAN LUIZ; PORTO DECHANDT, CARLOS ROBERTO; FERNANDES, JAQUELINE CRISTINA; NUNES RODRIGUES ALVES, ANA PAULA; SCHEUCHER, PRISCILA SANTOS; SIMOES, BELINDA PINTO; et al. Metformin exerts multitarget antileukemia activity in JAK2(V617F)-positive myeloproliferative neoplasms. CELL DEATH & DISEASE, v. 9, FEB 22 2018. Web of Science Citations: 2. (15/02200-2, 14/23092-0)
LIMA, KELI; COELHO-SILVA, JUAN LUIZ; KINKER, GABRIELA SARTI; PEREIRA-MARTINS, DIEGO ANTONIO; TRAINA, FABIOLA; CARLOS MAGNO FERNANDES, PEDRO AUGUSTO; MARKUS, REGINA PEKELMANN; LUCENA-ARAUJO, ANTONIO ROBERTO; MACHADO-NETO, JOAO AGOSTINHO. PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia. CANCER GENETICS, v. 233, p. 56-66, APR 2019. Web of Science Citations: 0. (17/24993-0)
DE ALMEIDA, BRUNA OLIVEIRA; MACHADO-NETO, JOAO AGOSTINHO. Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes. BMB REPORTS, v. 53, n. 8, p. 413-418, AUG 31 2020. Web of Science Citations: 0. (19/23864-7, 17/24993-0, 19/25421-5)
DE ALMEIDA, LARISSA COSTA; BAUERMEISTER, ANELIZE; REZENDE-TEIXEIRA, PAULA; DOS SANTOS, EVELYNE ALVES; BERALDO DE MORAES, LUIZ ALBERTO; MACHADO-NETO, JOAO AGOSTINHO; COSTA-LOTUFO, LETICIA VERAS. Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells. Biochemical Pharmacology, v. 168, p. 38-47, OCT 2019. Web of Science Citations: 1. (18/17595-0, 14/50926-0, 15/17177-6, 17/17648-4, 17/24993-0)
MACHADO-NETO, JOAO AGOSTINHO; COELHO-SILVA, JUAN LUIZ; DE SOUZA SANTOS, FABIO PIRES; SCHEUCHER, PRISCILA SANTOS; CAMPREGHER, PAULO VIDAL; HAMERSCHLAK, NELSON; REGO, EDUARDO MAGALHAES; TRAINA, FABIOLA. Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2(V617F) cells. INVESTIGATIONAL NEW DRUGS, v. 38, n. 3, p. 733-745, JUN 2020. Web of Science Citations: 0. (14/50947-7, 14/23092-0, 17/19864-6, 13/08135-2)