CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Has bachelor's degree in Biology (CEUSNP, 2009), Master's degree in Internal Medicine (Unicamp, 2011), PhD in Sciences with focus in Internal Medicine (Unicamp, 2015) and Postdoctoral in Internal Medicine (FMRP - USP-RP, 2015-2017). He is currently Assistant Professor at the Department of Pharmacology of the Institute of Biomedical Sciences of the University of São Paulo (ICB - USP) and develops research focused on the identification and characterization of antineoplastics and on the investigation of expression, activation and function of genes involved in signaling pathways cell alterations in cancer, especially hematological malignancies. (Source: Lattes Curriculum)
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Acute leukemias are aggressive hematological malignancies characterized by clonal proliferation with replacement and accumulation of neoplastic cells in the bone marrow, peripheral blood and other organs that suppress normal hematopoiesis. Despite the great advances in understanding the complexity involved in the molecular changes of acute leukemia in recent years, very little has been tr…
Acute leukemias comprise a group of hematological malignancies characterized by the expansion of blasts in bone marrow and peripheral blood, which is mainly due to the loss of differentiation ability of stem cells to functional cells in terminal stage, deregulation of proliferation and resistance to apoptosis. The mortality of adult patients with acute leukemia is very high, making it imp…
Acute leukemias are aggressive neoplasms characterized by clonal proliferation with replacement and accumulation of neoplastic cells (e20%) in bone marrow and other organs and can be classified as acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) when there is involvement of myeloblasts or lymphoblasts, respectively. Despite great advances in understanding the complexity …
Lung cancer is the most incident neoplasm in the world, with the exception of no melanoma skin cancer. In 2018 it was diagnosed in nearly 2 million people, and it was responsible for around 18,4% of the deaths among all types of cancer. Molecular mechanisms play a role in different tumor aspects, such as aggressiveness, and, although those mechanisms have already been studied, they are st…
Although widely studied, the molecular basis of breast cancer is still unclear, and the relevance of identifying new molecular markers and signaling pathways that may be useful in prognostic stratification, predicting response to therapy, and developing breast cancer new therapeutic options is evident. In this sense, the Ankyrin Repeat and KH Domain Containing 1 protein, ANKHD1, has been …
Gliomas belong to a heterogeneous group of brain tumors with distinct biological and clinical properties that include molecular complexity, as well as inconsistencies in histopathological classification, resulting in an inaccurate prediction of disease progression and failure to use standard therapy. A challenge for the treatment of gliomas is the high recurrence rates. Despite the great …
Acute leukemias are aggressive neoplasias characterized by clonal proliferation with replacement and accumulation of neoplastic blasts in bone marrow or peripheral blood. Despite great advances in understanding the complexity behind the molecular changes in acute leukemia in recent years, very little has been translated into new therapies. Stathmin 1 is a microtubule destabilizing protein…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 8 / 8 | Completed scholarships in Brazil |
| 12 / 12 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 20 |
| Cit./Article | 1.8 |
| Data from Web of Science | |
VICARI, HUGO PASSOS; LIMA, KELI; GOMES, RALPH DA COSTA; FERNANDES, DANIARA CRISTINA; LIPRERI DA SILVA, JEAN CARLOS; RODRIGUES JUNIOR, MANOEL TRINDADE; BARROSO DE OLIVEIRA, ALINE SILVA; DOS SANTOS, RICARDO NASCIMENTO; ANDRICOPULO, ADRIANO DEFINI; COELHO, FERNANDO; et al. Synthetic cyclopenta [b] indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells. European Journal of Pharmacology, v. 894, MAR 5 2021. Web of Science Citations: 0. (19/01700-2, 13/07600-3, 19/23864-7, 15/17177-6, 17/24993-0)
HIRAKATA, CAMILA; LIMA, KELI; DE ALMEIDA, BRUNA OLIVEIRA; DE MIRANDA, LIVIA BASSANI LINS; FLORENCIO, KATHARINE GURGEL DIAS; FURTADO, LUCIANA COSTA; COSTA-LOTUFO, LETICIA VERAS; MACHADO-NETO, JOAO AGOSTINHO. Targeting glioma cells by antineoplastic activity of reversine. Oncology Letters, v. 22, n. 2, AUG 2021. Web of Science Citations: 0. (15/17177-6, 18/19372-9, 19/23864-7)
LIPRERI DA SILVA, JEAN CARLOS; COELHO-SILVA, JUAN LUIZ; LIMA, KELI; VICARI, HUGO PASSOS; LAZARINI, MARIANA; COSTA-LOTUFO, LETICIA VERAS; TRAINA, FABIOLA; MACHADO-NETO, JOAO AGOSTINHO. Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia. CELLULAR ONCOLOGY, JUL 2021. Web of Science Citations: 0. (17/24993-0, 19/23864-7, 15/17177-6)
DE ALMEIDA, LARISSA COSTA; CALIL, FELIPE ANTUNES; MACHADO-NETO, JOAO AGOSTINHO; COSTA-LOTUFO, LETICIA VERAS. DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy. CANCER GENETICS, v. 252, p. 6-24, APR 2021. Web of Science Citations: 6. (19/23864-7)
CARLOS, JORGE ANTONIO ELIAS GODOY; LIMA, KELI; COSTA-LOTUFO, LETICIA VERAS; LEITAO, ANDREI; MACHADO-NETO, JOAO AGOSTINHO. AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis. INVESTIGATIONAL NEW DRUGS, v. 39, n. 4, p. 1139-1149, AUG 2021. Web of Science Citations: 0. (18/15904-6, 15/17177-6, 19/23864-7, 18/19372-9, 17/24993-0)
LIMA, KELI; COELHO-SILVA, JUAN LUIZ; KINKER, GABRIELA SARTI; PEREIRA-MARTINS, DIEGO ANTONIO; TRAINA, FABIOLA; CARLOS MAGNO FERNANDES, PEDRO AUGUSTO; MARKUS, REGINA PEKELMANN; LUCENA-ARAUJO, ANTONIO ROBERTO; MACHADO-NETO, JOAO AGOSTINHO. PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia. CANCER GENETICS, v. 233, p. 56-66, APR 2019. Web of Science Citations: 0. (17/24993-0)
DE ALMEIDA, LARISSA COSTA; BAUERMEISTER, ANELIZE; REZENDE-TEIXEIRA, PAULA; DOS SANTOS, EVELYNE ALVES; BERALDO DE MORAES, LUIZ ALBERTO; MACHADO-NETO, JOAO AGOSTINHO; COSTA-LOTUFO, LETICIA VERAS. Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells. Biochemical Pharmacology, v. 168, p. 38-47, OCT 2019. Web of Science Citations: 1. (18/17595-0, 17/17648-4, 17/24993-0, 14/50926-0, 15/17177-6)
MACHADO-NETO, JOAO AGOSTINHO; CAMPOS, PAULA DE MELO; FAVARO, PATRICIA; LAZARINI, MARIANA; SANTOS DUARTE, ADRIANA DA SILVA; LORAND-METZE, IRENE; COSTA, FERNANDO FERREIRA; OLALLA SAAD, SARA TERESINHA; TRAINA, FABIOLA. Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2(V617F) cells. ONCOTARGET, v. 6, n. 30, p. 29573-29584, OCT 6 2015. Web of Science Citations: 7. (14/23092-0, 12/09982-8, 11/51959-0, 11/06840-5)
DE ALMEIDA, BRUNA OLIVEIRA; MACHADO-NETO, JOAO AGOSTINHO. Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes. BMB REPORTS, v. 53, n. 8, p. 413-418, AUG 31 2020. Web of Science Citations: 1. (19/23864-7, 17/24993-0, 19/25421-5)
MACHADO-NETO, JOAO AGOSTINHO; FENERICH, BRUNA ALVES; SCOPIM-RIBEIRO, RENATA; EIDE, CHRISTOPHER A.; COELHO-SILVA, JUAN LUIZ; PORTO DECHANDT, CARLOS ROBERTO; FERNANDES, JAQUELINE CRISTINA; NUNES RODRIGUES ALVES, ANA PAULA; SCHEUCHER, PRISCILA SANTOS; SIMOES, BELINDA PINTO; et al. Metformin exerts multitarget antileukemia activity in JAK2(V617F)-positive myeloproliferative neoplasms. CELL DEATH & DISEASE, v. 9, FEB 22 2018. Web of Science Citations: 2. (14/23092-0, 15/02200-2)
LIMA, KELI; COELHO-SILVA, JUAN LUIZ; KINKER, GABRIELA SARTI; PEREIRA-MARTINS, DIEGO ANTONIO; TRAINA, FABIOLA; CARLOS MAGNO FERNANDES, PEDRO AUGUSTO; MARKUS, REGINA PEKELMANN; LUCENA-ARAUJO, ANTONIO ROBERTO; MACHADO-NETO, JOAO AGOSTINHO. PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia. CANCER GENETICS, v. 233, p. 56-66, APR 2019. Web of Science Citations: 0. (17/24993-0)
DE ALMEIDA, LARISSA COSTA; BAUERMEISTER, ANELIZE; REZENDE-TEIXEIRA, PAULA; DOS SANTOS, EVELYNE ALVES; BERALDO DE MORAES, LUIZ ALBERTO; MACHADO-NETO, JOAO AGOSTINHO; COSTA-LOTUFO, LETICIA VERAS. Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells. Biochemical Pharmacology, v. 168, p. 38-47, OCT 2019. Web of Science Citations: 1. (18/17595-0, 17/17648-4, 17/24993-0, 14/50926-0, 15/17177-6)
MACHADO-NETO, JOAO AGOSTINHO; CAMPOS, PAULA DE MELO; FAVARO, PATRICIA; LAZARINI, MARIANA; SANTOS DUARTE, ADRIANA DA SILVA; LORAND-METZE, IRENE; COSTA, FERNANDO FERREIRA; OLALLA SAAD, SARA TERESINHA; TRAINA, FABIOLA. Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2(V617F) cells. ONCOTARGET, v. 6, n. 30, p. 29573-29584, OCT 6 2015. Web of Science Citations: 7. (14/23092-0, 12/09982-8, 11/51959-0, 11/06840-5)
DE ALMEIDA, BRUNA OLIVEIRA; MACHADO-NETO, JOAO AGOSTINHO. Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes. BMB REPORTS, v. 53, n. 8, p. 413-418, AUG 31 2020. Web of Science Citations: 1. (19/23864-7, 17/24993-0, 19/25421-5)
MACHADO-NETO, JOAO AGOSTINHO; FENERICH, BRUNA ALVES; SCOPIM-RIBEIRO, RENATA; EIDE, CHRISTOPHER A.; COELHO-SILVA, JUAN LUIZ; PORTO DECHANDT, CARLOS ROBERTO; FERNANDES, JAQUELINE CRISTINA; NUNES RODRIGUES ALVES, ANA PAULA; SCHEUCHER, PRISCILA SANTOS; SIMOES, BELINDA PINTO; et al. Metformin exerts multitarget antileukemia activity in JAK2(V617F)-positive myeloproliferative neoplasms. CELL DEATH & DISEASE, v. 9, FEB 22 2018. Web of Science Citations: 2. (14/23092-0, 15/02200-2)
MACHADO-NETO, JOAO AGOSTINHO; COELHO-SILVA, JUAN LUIZ; DE SOUZA SANTOS, FABIO PIRES; SCHEUCHER, PRISCILA SANTOS; CAMPREGHER, PAULO VIDAL; HAMERSCHLAK, NELSON; REGO, EDUARDO MAGALHAES; TRAINA, FABIOLA. Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2(V617F) cells. INVESTIGATIONAL NEW DRUGS, v. 38, n. 3, p. 733-745, JUN 2020. Web of Science Citations: 0. (14/50947-7, 14/23092-0, 17/19864-6, 13/08135-2)