graduate at Biologia from Universidade Presbiteriana Mackenzie (1996), master's at Veterinary Medicine from Universidade de São Paulo (1999) and ph.d. at Pharmacology from Universidade de São Paulo (2003). Has experience in Pharmacology, focusing on General Pharmacology, acting on the following subjects: antinocicepção, veneno de crotalus durissus terrificus, hiperalgesia, veneno de bothrops asper and veneno de serpentes crotalus durissus terrificus. (Source: Lattes Curriculum)
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The Butantan Institute is strongly committed to public health and, therefore, to actions related to combating COVID-19. The sectors or centers of the Butantan Institute, namely the Development and Innovation Center, the Scientific Development Center, the Bioindustrial Development Center and the Cultural Development Center, came together to develop projects to fight the pandemic. Consideri…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Crotoxin (CTX) is a neurotoxin isolated from Crotalus durissus terrificus snake venom that exhibits anti-inflammatory, immunomodulatory and antitumor activities. In this sense, many studies have demonstrated that CTX exerts a striking antitumor effect in several types of tumor, such as Cutaneous Melanoma, a disease without cure. On the other hand, recently, our group has demonstrated that…
Chronic pain, when compared with other diseases, is one of the most disabling and one type of pain that generates higher costs to healthcare services, becoming a public health problem. This condition may have an inflammatory origin or can be developed due to peripheral nerve injury, and it is often associated with other disorders such as multiple sclerosis (an example of an autoimmune dis…
Multiple sclerosis (MS) is a Central Nervous System inflammatory demyelinating disease that has as primary symptoms losses of sensory and motor functions and chronic pain as a major concern, affecting 50% to 80% of patients. MS has no cure, being the therapeutic approaches focused on stopping disease progression and cumulative neurological disability. To date, however, few studies have in…
(Only some records are available in English at this moment)
Crotoxin (CTX) is a neurotoxin isolated from Crotalus durissus terrificus snake venom that exhibits anti-inflammatory, immunomodulatory and antitumor activities. In this sense, many studies have demonstrated that CTX exerts a striking antitumor effect in several types of tumor, such as cutaneous melanoma, a disease without cure. On the other hand, recently, our group has demonstrated that…
Chronic pain affects around 30% of the world's population. The treatment for this condition is still a challenge, becoming interesting the study of new drugs and new molecular targets capable to modulate the nociceptive system. Crotalphine is a peptide isolated from the South American Crotalus durissus terrificus snake venom, which synthetic analog has long-acting analgesic action in acut…
(Only some records are available in English at this moment)
Chronic pain affects around 30 % of the world's population. Treatment for this condition is still a challenge, becoming interesting the study of new drugs and new molecular targets capable to modulate the nociceptive system. Crotalphine is a synthetic peptide (patent PI 0502399-8 granted 05/05/2018) originally isolated from the South American Crotalus durissus terrificus snake venom, whic…
Studies develop in the last years in our lab, using compounds obtained from animal venoms or toxins, resulted in the discovery of crotalfina, a peptide of 14 amino acids that had its sequence based on natural painkiller factor obtained from the venom of Crotalus durissus terrificus. Studies demonstrated that crotalfina induces long-lasting antinociception (2-3 days in the chronic pain mod…
| 2 / 2 | Ongoing research grants |
| 6 / 6 | Completed research grants |
| 11 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 21 / 18 | All research grants and scholarships |
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CV Lattes
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