| Grant number: | 11/17974-2 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2012 |
| End date: | July 31, 2014 |
| Field of knowledge: | Biological Sciences - Pharmacology - General Pharmacology |
| Principal Investigator: | Gisele Picolo |
| Grantee: | Gisele Picolo |
| Host Institution: | Instituto Butantan. São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
Abstract
Multiple sclerosis (MS) is a Central Nervous System inflammatory demyelinating disease that has as primary symptoms losses of sensory and motor functions and chronic pain as a major concern, affecting 50% to 80% of patients. MS has no cure, being the therapeutic approaches focused on stopping disease progression and cumulative neurological disability. To date, however, few studies have investigated the mechanisms of chronic pain in animal models of MS since locomotor impairments difficult the pain evaluation. Recently, it was demonstrated that in the MOG35-55-induced Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS, the hypernociception appears before the onset of motor disability, allowing the study of these two phenomena separately. Crotoxin is a neurotoxin isolated from the Crotalus durissus terrificus snake venom that displays antinociceptive, anti-inflammatory and immunomodulatory effects. Then, the aim of this study is to evaluate the effect of crotoxin in the pain and in symptoms progression of EAE. (AU)
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