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Effect of crotoxin in the pain and in the clinical signs observed in animals with experimental autoimmune encephalomyelitis, a model of multiple sclerosis

Grant number: 11/17974-2
Support type:Regular Research Grants
Duration: February 01, 2012 - July 31, 2014
Field of knowledge:Biological Sciences - Pharmacology - General Pharmacology
Principal Investigator:Gisele Picolo
Grantee:Gisele Picolo
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Multiple sclerosis (MS) is a Central Nervous System inflammatory demyelinating disease that has as primary symptoms losses of sensory and motor functions and chronic pain as a major concern, affecting 50% to 80% of patients. MS has no cure, being the therapeutic approaches focused on stopping disease progression and cumulative neurological disability. To date, however, few studies have investigated the mechanisms of chronic pain in animal models of MS since locomotor impairments difficult the pain evaluation. Recently, it was demonstrated that in the MOG35-55-induced Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS, the hypernociception appears before the onset of motor disability, allowing the study of these two phenomena separately. Crotoxin is a neurotoxin isolated from the Crotalus durissus terrificus snake venom that displays antinociceptive, anti-inflammatory and immunomodulatory effects. Then, the aim of this study is to evaluate the effect of crotoxin in the pain and in symptoms progression of EAE. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TEIXEIRA, N. B.; SANT'ANNA, M. B.; GIARDINI, A. C.; ARAUJO, L. P.; FONSECA, L. A.; BASSO, A. S.; CURY, Y.; PICOLO, G. Crotoxin down-modulates pro-inflammatory cells and alleviates pain on the MOG(35-55)-induced experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. BRAIN BEHAVIOR AND IMMUNITY, v. 84, p. 253-268, FEB 2020. Web of Science Citations: 0.
KIMURA, LOUISE FAGGIONATO; DE MOURA MATTARAIA, VANIA GOMES; PICOLO, GISELE. Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats. Behavioural Brain Research, v. 364, p. 442-446, MAY 17 2019. Web of Science Citations: 5.
ZAMBELLI, VANESSA O.; PICOLO, GISELE; FERNANDES, CARLOS A. H.; FONTES, MARCOS R. M.; CURY, YARA. Secreted Phospholipases A(2) from Animal Venoms in Pain and Analgesia. TOXINS, v. 9, n. 12 DEC 2017. Web of Science Citations: 10.

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