Effect of crotoxin in the pain and in the clinical signs observed in animals with experimental autoimmune encephalomyelitis, a model of multiple sclerosis

• Grant number: 11/17974-2
• Support Opportunities: Regular Research Grants
• Duration: February 01, 2012 - July 31, 2014
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Gisele Picolo
• Grantee: Gisele Picolo
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Multiple sclerosis (MS) is a Central Nervous System inflammatory demyelinating disease that has as primary symptoms losses of sensory and motor functions and chronic pain as a major concern, affecting 50% to 80% of patients. MS has no cure, being the therapeutic approaches focused on stopping disease progression and cumulative neurological disability. To date, however, few studies have investigated the mechanisms of chronic pain in animal models of MS since locomotor impairments difficult the pain evaluation. Recently, it was demonstrated that in the MOG35-55-induced Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS, the hypernociception appears before the onset of motor disability, allowing the study of these two phenomena separately. Crotoxin is a neurotoxin isolated from the Crotalus durissus terrificus snake venom that displays antinociceptive, anti-inflammatory and immunomodulatory effects. Then, the aim of this study is to evaluate the effect of crotoxin in the pain and in symptoms progression of EAE. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZAMBELLI, VANESSA O.; PICOLO, GISELE; FERNANDES, CARLOS A. H.; FONTES, MARCOS R. M.; CURY, YARA. Secreted Phospholipases A(2) from Animal Venoms in Pain and Analgesia. TOXINS, v. 9, n. 12, DEC 2017. (13/07467-1, 15/01254-1, 11/17974-2)

TEIXEIRA, N. B.; SANT'ANNA, M. B.; GIARDINI, A. C.; ARAUJO, L. P.; FONSECA, L. A.; BASSO, A. S.; CURY, Y.; PICOLO, G.. Crotoxin down-modulates pro-inflammatory cells and alleviates pain on the MOG(35-55)-induced experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. BRAIN BEHAVIOR AND IMMUNITY, v. 84, p. 253-268, FEB 2020. (11/17974-2, 10/12903-7, 13/07467-1)

KIMURA, LOUISE FAGGIONATO; DE MOURA MATTARAIA, VANIA GOMES; PICOLO, GISELE. Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats. Behavioural Brain Research, v. 364, p. 442-446, MAY 17 2019. (11/17974-2, 13/20795-8, 08/57898-0)

TEIXEIRA, NATHALIA BERNARDES; PICOLO, GISELE; GIARDINI, ALINE CAROLINA; BOUMEZBEUR, FAWZI; POTTIER, GERALDINE; KUHNAST, BERTRAND; SERVENT, DENIS; BENOIT, EVELYNE. Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis. JOURNAL OF NEUROINFLAMMATION, v. 17, n. 1, p. 14-pg., 2020-09-07. (13/07467-1, 11/17974-2)