Effect of crotoxin in the Experimental Autoimmune Encephalomyelitis, a model of multiple sclerosis: Evaluation of the nociception and clinical symptoms.

• Grant number: 10/12903-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2011
• End date: December 31, 2012
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Gisele Picolo
• Grantee: Nathália Bernardes Teixeira
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Multiple sclerosis (MS) is an inflammatory autoimmune disease that induces loss of motor and sensory function. Included in these alterations, chronic pain is a major concern affecting 50 and 80% of MS patients, interfering with many aspects of their life. It is important to point out that MS has no cure, been the therapeutic approaches concentrated in stop the disease progression and cumulative neurological disability.Although the importance of pain symptoms to MS patients, only recently pain has been systematically studied in MS patients, since motor dysfunctions that arises due to lesions in the central nervous system difficult the pain evaluation. Experimental autoimmune encephalomyelitis (EAE) is an accepted animal model of MS that shares many features of the pathology seen in MS patients, including widespread CNS inflammation, demyelization and locomotor impairments. In the model of MOG35-55-induced EAE, it was observed that hypernociception appears before the onset of motor disability.Then, the aim of this study is to evaluate the effect of crotoxin, a neurotoxin isolated from the venom of Crotalus durissus terrificus rattlesnake that induces antinociceptive, anti-inflammatory and immunomodulatory effect, in the pain and in the symptom progression of Experimental autoimmune encephalomyelitis, a animal model of multiple sclerosis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TEIXEIRA, N. B.; SANT'ANNA, M. B.; GIARDINI, A. C.; ARAUJO, L. P.; FONSECA, L. A.; BASSO, A. S.; CURY, Y.; PICOLO, G.. Crotoxin down-modulates pro-inflammatory cells and alleviates pain on the MOG(35-55)-induced experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. BRAIN BEHAVIOR AND IMMUNITY, v. 84, p. 253-268, FEB 2020. (11/17974-2, 10/12903-7, 13/07467-1)