Abstract
Signaling through the fibroblast growth factor (FGF) eventually became a rather complex growth signaling pathway, reflecting the wide range of physiological functions controlled via FGF-FGFR (fibroblast growth factor receptor). The FGF family in mammals consists of 18 ligands that exert their functions through 4 transmembrane receptors with tyrosine kinase activity (FGFR1, FGFR2, FGFR3 an…