CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Farmácia from Universidade Federal de Alfenas (1989), master's at Pharmacology from Universidade Estadual de Campinas (1995) and doctorate at Chemistry from Universidade Estadual de Campinas (1999). Has experience in Pharmacology, focusing on Pharmacology Molecular Biochemistry, acting on the following subjects: metabólitos secundários, atividade antifúngica, atividade antimicobacteriana, fungos and fungos de manguezais. (Source: Lattes Curriculum)
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| Biological silver |
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Fungi are sources of a wide diversity of secondary metabolites that can present distinct pharmacological properties and potential for pharmaceutical use. Among these compounds, a few species are able to produce alpha-pyrone derivatives as annularins with cytotoxicity and antimicrobial activity. In a previous study performed by our group, an annularin derivative showed action on the repair…
The secondary metabolite monocerin is produced by the fungus Exserohilum rostratum, and in this study, efforts will be applied for obtaining a mutant strain able to produce this compound with higher yield than the wild strain.Due to the therapeutic potential in wounds and injuries, the monocerin will be incorporated in a pharmaceutical formulation, such as a cream, for topical application…
Anularin FV3 is a secondary metabolite obtained from fungal Exserohilum rostratum, which failed to show in vitro antitumoral activity in the tumoral cell lines K-562 (human leukemia) and on B16F10 (murine melanome). However, this compound induced proliferation of the human umbilical vein endothelial cells (HUVECs) that was five times higher than in the control group. Based on this observa…
Fungal infections are frequent and responsible for high morbidity and mortality especially in immune-sensitive patients. Treatment with the currently available antifungal substances is long and causes various collateral effects, which justifies the search for new antifungal agents. The Brazilian biodiversity represents a straight and viable source of new molecules to be applied by the che…
(Only some records are available in English at this moment)
Fungi produce a wide variety of secondary metabolites that may have distinct pharmacological properties. Although many biosynthetic gene clusters responsible for encoding the expression of these metabolites can be silenced under laboratory culture conditions, the epigenetic modulation is a promising strategy to increase the production of specific metabolites, or promote the biosynthesis o…
Data from the United States National Cancer Institute show that death rates from cancer have increased over the years, and the available therapy indicates adverse effects on patients, requiring new alternatives. Biological silver nanoparticles (AgNPs) can be a viable possibility as antitumor treatment, since the protective coating favors its affinity for tumor cells and, consequently, can…
The most widely studied nanomaterials are metallic nanoparticles, and among these, silver nanoparticles (AgNPs) is one of the promising candidate exist in nature. Therefore, the studies will highlight various possibilities of applications of AgNPs in the field of medical, food, pharmaceutical, diagnostic, and many others. To consider the biotechnological potential of AgNPs application, it…
New antifungal drugs with specific activity or with wide action spectrum, in addition to minimal side effects are necessary to improve the treatment of fungal infections.There is a wide biodiversity in different ecosystems, which is only partially explored. The goal of this project aims to employ Antarctic isolated bacterium as source of new antifungal agents.Antifungal activity of org…
(Only some records are available in English at this moment)
Nanoparticles, such as silver nanoparticles (AgNPs), are one of promising candidates for biomedical and pharmaceutical use. Mycogenic AgNPs, coded as AgNP-AT, were previously obtained extracellularly using the fungus Aspergillus tubingensis, and characterized physical and chemically via size measurement, polydispersity index (PDI), zeta potential through dynamic light scattering (DLS), tr…
| 1 / 1 | Ongoing grants |
| 7 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 4 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 21 / 13 | All research grants and scholarships |
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