Aloisio de Andrade Bartolomeu

• Abstract

  The biological relevance of biomolecules prone to undergo phosphorylation and dephosphorylation processes is associated to their ability to control the biological role of kinase and phosphatase proteins. Several phosphorylated or phosphonylated organic compounds act as inhibitors or chemical probes for the aforementioned enzymes. This research proposal aims the preparation of phosphoryl, …

  Preparation and biological evaluation of phosphoryl and phosphonyl derivatives of goniothalamin and piplartine, BP.PD

• Abstract

  Porphyrins and Phthalocyanines are compounds which have been extensively studied as photosensitizers in different areas, including photodynamic therapy (PDT), production of semiconductors, gas sensors, dye-sensitized solar cells, liquid crystals, among other applications. Thus, in this research project, we propose to carry out the synthesis of new phthalocyanine-type photosensitizers star…

  Synthesis of high conjugated phthalocyanine and porphyrin derivatives: strategies using RMCs and Diels-Alder reactions, BP.DR

• Abstract

  The synthesis of dibenzoxanthenes and 4-aryl-3,4-dihydrocoumarins (neoflavonones) is of great interest in the field of organic chemistry because they are rare and less abundant compounds in natural products, respectively. In addition, both moieties are found in natural and synthetic molecules which present applications as anti-inflammatory, antioxidant and antimicrobial agents. The one-po…

  Synthesis of 14-Aryl-14H-dibenzo[a,j]xanthenes and 4-Aryl-3,4-dihydro-benzo[f]coumarins promoted by niobium pentachloride, with potential application in the preparation of dyes-sensitizers for use in Grätzel devices., BP.MS

(Only some records are available in English at this moment)

• Abstract

  Molecules containing a sulfonyl (-SO2-) functionality are valuable building blocks in organic synthesis, medicinal chemistry, and pharmaceutical industry. Over the last few years, there has been an increasing interest in the development of methods for the synthesis of the sulfonyl moiety by direct incorporation of SO2. This research project aims the preparation of sulfones using an electr…

  Electrochemical synthesis of sulfones via three-component reaction between alkyl carboxylic acids, sulfur dioxide, and tetrahydroisoquinolines/tetrahydro-beta-carbolines, BE.EP.PD

• Abstract

  Studies on the direct photocatalyzed C-H arylation of quinolines, pyridines and styrenes with aryldiazonium and diaryliodonium salts will be performed using visible light. Different photocatalysts or the use of EDA complexes will also be explored in batch and flow conditions. To the best of our knowledge, photoarylation of these substrates has not been well-explored yet in the absence of …

  Direct C-H photocatalyzed arylation of quinolines, pyridines and styrenes with aryldiazonium and diaryliodonium salts, BE.EP.DR