Abstract
The relationship between serotonergic dysfunction and schizophrenia began with the discovery of the effects of lysergic acid diethylamide (LSD) which has high affinity for the 5-HT2A receptor. Its activation generates delusions and hallucinations that are positive symptoms of schizophrenia. Another substance, 2,5-dimethoxy-4-iodoamphetamine (DOI), also exhibits hallucinogenic properties b…