CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Odontologia from Universidade Estadual de Campinas (1983), master's at Fisiologia e Biofísica from Universidade Estadual de Campinas (1992) and doctorate at Pós Graduação em Fisiologia e Biofísica from Universidade Estadual de Campinas (1998). Has experience in Physiology, acting on the following subjects: atp, receptor purinergico p2x3, nmda pain trigeminal nucleus, pain nmda trigeminal nucleus and temporomandibular. (Source: Lattes Curriculum)
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The dorsal root ganglion is an important site of pain modulation. Studies from our and others laboratories have been suggested that the interaction between neurons and glial satellite cells is important in the development of inflammatory hyperalgesia as well as neuropathic hyperalgesia. Many molecules involved in this interaction emerge as a promising pharmacological target to differently…
Diabetic Peripheral Neuropathy (DPN) manifests in 60% of diabetic patients and counts for one of the major causes of peripheral members amputation. Besides, diabetes is responsible for 30% of all neuropathic pain diagnosed. Even though the electrophysiological and morphological aspects are well described, little is known about its development and progression, impossibilitating effective t…
(Only some records are available in English at this moment)
Epidemiological studies highlight the association between social stress and the development of depression and anxiety, as well as the comorbidity between these disorders and chronic pain. Chronic pain causes suffering and even disability, having high clinical relevance and impact on quality of life. The participation of the mesolimbic dopaminergic system in the chronification of pain has …
Osteoarthritis (OA) is one of the main causes of morbidity in the world population, being one of the main factors of occupational incapacity in countries like United States and Brazil. Chronic pain associated with OA is the main phenomenon that translates the incapacitation in the individuals affected, generating a direct impact on their quality of life. OA pain therapy is limited and uns…
ATP (adenosine triphosphate), initially known as an intracellular energy source, plays an important role in intercellular communication in physiological and pathological conditions. This molecule appears to be important in the development of inflammatory hyperalgesia in the peripheral nervous system and is considered an important mediator in the communication between primary afferent neur…
Rheumatoid Arthritis (RA) is an autoimmune, systemic and chronic disease of inflammatory origin that affects mainly the lining of the joints and its structures and other connective tissues, dramatically impacting the patient's quality of life and, although the contribution of genetic and environmental factors to disease development are well known, those driving to autoimmunity remains unc…
(Only some records are available in English at this moment)
Under certain pathologic conditions as peripheral tissue injury, sensory pathway can be modified. In this case, pain signal is followed by a process named hyperalgesia. This phenomenon is a result of nociceptive fibers sensitization, which cause decrease of threshold neuronal excitability. This reduction is due to action of several mediators produced by inflammatory process. These mediato…
Approximately 50% of the diabetic patients develop peripheral neuropathy with irreversible complications to the peripheral nervous system. Hyperglycemia is the majoritarian cause of oxidative stress and promotes a suitable environment to damage peripheral nerves and neurotransmitter pathways. Nociceptors could be selectively affected by low-level laser therapy (LLLT), and it has been prop…
When an intense stimulus results in tissue injury or inflammation, the associated pain is characterized by an ongoing pain sensation and appearance of enhanced response to mild noxious or non-aversive stimuli reflecting states of hyperalgesia and allodynia, respectively. Typically, these exaggerated pain states resolve with resolution of the inflammation or wound healing. However, there a…
(Only some records are available in English at this moment)
| 12 / 8 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 23 / 17 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 43 / 33 | All research grants and scholarships |
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