The role of Brain-Derived Neurotrophic Factor (BDNF) in treatment with platelet-rich plasma in experimental model of Osteoarthritis

• Grant number: 18/10205-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2019
• End date: February 28, 2021
• Field of knowledge: Biological Sciences - Physiology
• Principal Investigator: Carlos Amilcar Parada
• Grantee: Kauê Franco Malange
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Osteoarthritis (OA) is one of the main causes of morbidity in the world population, being one of the main factors of occupational incapacity in countries like United States and Brazil. Chronic pain associated with OA is the main phenomenon that translates the incapacitation in the individuals affected, generating a direct impact on their quality of life. OA pain therapy is limited and unsatisfactory, made by the use of corticosteroids and anti-inflammatories, which in chronic use, harm patients' clinical status, offering few benefits. In this sense, the use of regenerative therapies such as Platelet-Rich Plasma (PRP) has been highlighted because of its greater effectiveness in the treatment of OA. The presence of several growth factors in the platelets, released through its activation, increase the tissue regeneration of the patients, providing a better prognosis compared to other therapies used in OA treatment. However, despite the promising character, there is a lack of data regarding the molecular mechanisms by which PRP exhibits its action for tissue regeneration and analgesia of the joint compartment, especially in the cartilaginous tissue, one of the main targets of Osteoarthritis. Previously in-vitro studies have shown that peripherally, Brain-Derived Neurotrophic Factor (BDNF) acts on chondrocyte differentiation, aiding in the synthesis of cartilaginous tissue, and furthermore, contributes to macrophage modulation for anti-inflammatory phenotype. Thus, the present work aims to investigate the molecular mechanisms involved in the pharmacological action of BDNF, a neurotrophic growth factor present in platelets, during PRP therapy, in experimental Osteoarthritis model. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MALANGE, Kauê Franco. Brain-derived neurotrophic factor (BDNF) as an important protein for therapeutic effects of platelet-rich plasma in an experimental osteoarthritis model. 2021. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.