João Lauro Viana de Camargo

• Abstract

  The worldwide use of high amounts of pesticides is a matter of constant concern due to potential adverse effects on human health. Herbicides belongs to one of the most widely class of pesticides used in agriculture, being diuron, a compound derived from urea, the fifth most used in Brazil, despite its classification by the U.S. Environmental Protection Agency (USEPA) as "probably carcin…

  Cytotoxicity of diuron and its metabolites: mitochondrial dysfunction, cell death, genotoxicity and mutagenicity, AP.R

• Abstract

  This request seeks support for an one-week visit (October 10-19th, 2014) of Lora L. Arnold, M. Sc., from the Department of Pathology and Microbiology (DPM), Nebraska University Medical Center (UNMC), to the Department of Pathology, Medical School of Botucatu, UNESP, specifically to the Center for Assessment of Environmental Impact on Human Health (TOXICAM). Ms. Lora L. Arnold is assistan…

  Visit of Lora L. Arnold, M.Sc. to the Botucatu Medical School/TOXICAM: experimental urothelial carcinogenesis; good laboratory practices (GLP), AV.EXT

• Abstract

  Endocrine disrupting chemicals are substances able to interfere on the hormonal homeostasis in humans and other animals. Usually they have estrogenic or antiandrogenic activities. This proposal comprises projects that will evaluate in rats the potential of three enviromental agents jto exert endocrine disruption: 1) drinking water, 2) sewage sludge and 3) three agricultural fungicides pro…

  In vivo evaluation of potential endocrine disruption by environmental contaminants, AP.R

(Only some records are available in English at this moment)

• Abstract

  Endocrine disruptors (ED) are individual agents or mixtures, which can affect hormone function, such as regulation of steroids, which determine the phenotypical and functional characteristics, and sexual behavior of different species. Environmental substances with estrogenic activity (xenoestrogens) are the best-known endocrine disruptors and have been widely disseminated in the environme…

  In vivo activity of the estrogenic potential of water sample for human consumption produced by water treatmeant plant of São Paulo, BP.IC

• Abstract

  Testicular germ cell tumors (TGCT) represent over 90% of testicular tumors in humans and its incidence has been increasing in several regions, including in Brazil. Its causes are not known, however, cryptorchidism occurs in 10% of cases of TGCT. The influence of environmental factors on the incidence of TGCT becomes increasingly evident. Special attention has been paid to endocrine disrup…

  Establishment of a testicular germ cell tumor model in the Sprague-Dawley rat, BP.PD

• Abstract

  The diuron (3 - (3,4-dichlorophenyl) -1,1-dimethylurea) is a substituted urea herbicide widely used on sugarcane, cotton, and soybeans crops. This agent has been classified by the United States Environmental Protection Agency (USEPA, 2004) as "probably carcinogenic to humans " because it induced tumors in the bladder and renal pelvis of rats, and breast and skin of mice exposed to ration …

  Expressão do gene Glipican 3 (Gpc3) no urotélio da bexiga de ratos expostos ao diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) por 7 dias e 20 semanas, BP.IC

(Only some records are available in English at this moment)