CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine from the Federal University of Ceará (1991), Master of Sciences in Medicine (Nephrology) from the Federal University of São Paulo (1997), specialization in Transplantation Immunology at the University of Tours (Diplome des Etudes Appronfodies, France, 1997-1999), PhD in Medicine (Nephrology) by the Federal University of São Paulo (2000), postdoc at Imperial College London (2000-2003) and habilitation (Livre Docencia) at the Federal University of São Paulo (Medicine) in 2006. He is currently full professor of Department of Immunology at the Institute of Biomedical Sciences at the University of São Paulo (since 2011). He was Visiting Professor at the University of Tours, France in 2006. The laboratory has experience in nephrology area and in cellular and applied immunology, acting on the following topics: kidney transplantation, experimental models of acute and chronic kidney diseases, ischemia and reperfusion injury, regulatory cells and stem cells in kidney diseases. More recently, the laboratory has been studying the microbiota interface, cellular metabolism and inflammation in models of autoimmunity and allo. Full member of São Paulo Research Academy.Full member of Brazilian Academy of Sciences. CNPq 1A grantee award. Deputy Provost at the USP Graduate Office (2022-2023). (Source: Lattes Curriculum)
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The project focuses on investigating the immunological and inflammatory mechanisms that connect the skin, intestine, and other peripheral organs, with particular emphasis on the cellular and molecular pathways involved in chronic inflammatory and tumor-related diseases.The interconnection between the skin, intestine, and kidneys in inflammatory contexts highlights the skin's ability to in…
Chronic kidney diseases are still a leading cause of death worldwide. Thus, the need for new treatment approaches is urgent. Here, we aim to unravel new sensing mechanisms for organelles on renal and immune cells and how the external and internal perception of unbalance is involved in responses which triggers injury, influences repair, and promotes renal tissue fibrosis. We hypothesize th…
Chronic kidney diseases are still a leading cause of death worldwide. Thus, the need for new treatment approaches is urgent. Here, we aim to unravel new sensing mechanisms for organelles on renal and immune cells and how the external and internal perception of unbalance is involved in responses which triggers injury, influences repair, and promotes renal tissue fibrosis. We hypothesize th…
(Only some records are available in English at this moment)
Cisplatin is a potent antitumoral drug for diverse tumor types. However, its nephrotoxic adverse effects limit its clinical use in cancer therapy. Faced with this, several non-pharmacological approaches have been studied to minimize cisplatin-induced renal inflammation. One of these non-pharmacological approaches is caloric restriction, which several studies have demonstrated to be effici…
(Only some records are available in English at this moment)
The project will investigate how noncanonical stressors (pH changes, osmotic variations, and mechanical stimuli) modulate Ca²¿ homeostasis in renal cells and their organelles (endoplasmic reticulum, mitochondria, and lysosomes), and how this modulation affects genomic integrity and the activation of DNA repair mechanisms. Genetically modified cells expressing GCaMP calcium sensors, as wel…
This study investigates the relationship between the skin and peripheral organs, such as the gut and kidneys, during inflammatory processes. Scientific knowledge supports the notion that the skin is an organ with complex immunological functions, in which innate and adaptive immune systems interact in response to physical, chemical, and microbiological stimuli [1]. Being highly vascularize…
Diabetic kidney disease (DKD) is the most common microvascular complication of chronic hyperglycemia and the leading cause of end-stage renal disease (ESRD) worldwide. The renin-angiotensin-aldosterone system (RAAS) plays a central role in hemodynamic alterations, serving as the primary trigger of kidney damage in chronic kidney disease (CKD). Consequently, RAAS inhibitors and blockers ar…
(Only some records are available in English at this moment)
The hypoxic response in cells and tissues is mediated by hypoxia-inducible transcription factors (HIF), among which HIF-1¿ plays a key role in metabolic changes in response to oxygen availability. Macrophages, cells of the immune system, are present in all tissues of the body and accumulate in ischemic/hypoxic areas, worsening tissue injury by producing reactive oxygen species and other t…
Diabetic kidney disease (DKD) is a serious microvascular complication that develops in patients with type 1 (T1D) or type 2 (T2D) diabetes and may be related to the prevalence of end-stage renal disease, which requires dialysis or renal replacement therapy. In DKD, the proximal tubular epithelial cells (PTECs), due to excess sodium and glucose in the filtrate, present a more pronounced O2…
(Only some records are available in English at this moment)
O vírus linfotrópico de células T humanas tipo 1 (HTLV-1) é um retrovírus responsável por infectar milhões de pessoas em todo o mundo. Indivíduos infectados podem desenvolver doenças inflamatórias ou neoplásicas, como a mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP) e a leucemia/linfoma de células T do adulto (ATLL), respectivamente. Após a infecção, o vírus pode …
CD8¿ T cells are essential for immune recognition of foreign antigens and rely on glycolysis, fueled by NAD, to support their activation and proliferation. SARM1, a TLR adaptor protein known to degrade NAD, shows a dynamic expression depending on the activation state of CD8¿ T cells. We reasoned that SARM1 may regulate CD8¿ T cell function through NAD metabolism. Therefore, we will invest…
Transient receptor potential melastatin 5 channel (TRPM5) is a polymodal ion channel expressed in different cells of the body, including chemosensory and immune cells. It is an ion channel impermeable to calcium (Ca2+) but is activated by increased intracellular Ca2+. Ca2+ is an important intracellular second messenger for several cellular functions, especially in immune cells. Preliminar…
(Only some records are available in English at this moment)
Initially described for their role in taste and their abundant presence in oral cavity cells, taste receptors are chemoreceptors activated by environmental molecules that generate a response in the form of an electrical impulse, which is processed by the nervous system and creates the perception of taste. With the advance of studies on taste receptors, their presence in ectopic regions wa…
The gut microbiota has several immunoregulatory mechanisms that induce the host's immune tolerance against the microbiome throughout life. These organisms use fibers from the diet as nutrients for their metabolic fermentation, generating different types of shortchain fatty acids (SCFAs) as metabolic by-products. Among them, butyrate has been shown to induce Tregs, and its oral administrat…
The circadian rhythms are a cell-autonomous process that regulates the daily cycles of living species. In vertebrates, the circadian rhythms are controlled by an internal clock in a transcription-translation loop where the master genes clock and bmal induce the transcription of clock target genes, including its own repressors PER and CRY. Emerging studies have shown a relationship between…
(Only some records are available in English at this moment)
| 6 / 6 | Ongoing grants |
| 25 / 19 | Completed research grants |
| 15 / 15 | Ongoing scholarships in Brazil |
| 122 / 106 | Completed scholarships in Brazil |
| 5 / 5 | Ongoing scholarships abroad |
| 36 / 36 | Completed scholarships abroad |
| 209 / 187 | All research grants and scholarships |
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