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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
José Cesar Rosa Neto in research grants and scholarships supported by FAPESP.
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Our interest is to build a joint project aimed at investigating the effect of the novel training protocol named "Exercise Snacks." Prof. Jonathan Little pioneered this approach starting in 2019 when his lab showed that exercise snacks - short (<1 min) bouts of vigorous exercise performed sporadically throughout the day can improve cardiorespirtaory fitness in untrained adults (1). Subsequ…
Aging is enhanced by a gradual decline in numerous physiological processes, including changes in the immune system, which are collectively called immunosenescence, and circadian rhythms, which show age-related changes. The relationships between clock genes, aging and immunosenescence are not well understood. Monocytes and macrophages show high rhythmicity with a high amplitude of expressi…
Cancer has shown epidemic levels bringing considerable economic and social impact in modern society. Nowadays, cancer is the second cause of death in the world, with a high probability to become the principal cause of death in the next decade. Although several advances in the treatment, the life expectancy and quality of life of the patient can be affected by the chemotherapy. Our group …
The obesity is na epidemic condition in developed and development countries. The high consumption of fat acids in ocidental diet, and the sedentarism induced the body weight gain, and the accumulation of fat acids in depots of adipose tissue, and other organs, such as liver. This condition caused the low grade inflammation, condition that it is presented in the genesis of co-morbidates as…
Doxorubicin is an antibiotic of antracyclines family, that is the most to use in clinical practice, in treatment of solid tumours. However, this drug cause great cardiotoxicity. Moreover is common the patients development several fatigue and asthenia, during the treatment. Recents works showed that others organs are still injured by doxorubicin treatment, as adipose tissue, skeletal muscl…
Physical activity has demonstrated significant benefits in the prevention and treatment of cancer, providing more effective antitumor responses in athletes with high aerobic capacity compared to poorly trained or sedentary individuals. This finding highlights an intriguing relationship between physical exercise and immunity against cancer, suggesting that aerobic training can mitigate adv…
Monocytes are circulating immune cells that can migrate to peripheral tissues and differentiate into macrophages and dendritic cells. The final phenotype of these differentiated cells is influenced by the tissue microenvironment, particularly in tumor settings, where it can bias differentiation towards pro-tumoral phenotypes. Different subpopulations of monocytes exhibit varying responses…
The lack of physical activity is a triggering factor for numerous morbidities, in addition to being associated with worsening of chronic inflammatory diseases. The World Health Organization recommends a total of 150 minutes of vigorous physical exercise, or 300 minutes of moderate exercise per week for an adult individual to be considered active. In addition, another worrying factor in mo…
(Only some records are available in English at this moment)
Macrophages are immune cells present throughout the body and are essential for maintaining bodyhomeostasis. Its plasticity allows it to have different phenotypes that are capable of fightinginfections (M1) and promoting its modification and tissue repair (M2). Furthermore, the phenotypesthat are induced by different signals from the environment. Catecholamines (adrenaline andnoradrenaline…
The immune system is responsible for the body's defense and repair process, for this, it recognizes its own molecules and those that are not of the individual. In principle, the immune system is divided into innate and adaptive, being differentiated by the level of specificity of the cell receptors present in each one. All this is to maintain the homeostasis and integrity of the body. Wit…
Cancer is the disorderly and aggressive growth of cells, existing more than 100 types of cancer. This complex group of diseases is the second leading cause of death worldwide, second only to cardiovascular disease. Just in 2018, Brazil recorded a total of 224,712 deaths from cancer, 117,477 men and 107,235 women, of whom 17,572 (16.4%) were due to some type of breast cancer. It is estimat…
(Only some records are available in English at this moment)
Macrophages are immune cells present throughout the body that are essential for maintaining tissue homeostasis. Their remarkable plasticity allows them to acquire different phenotypes, capable of fighting infections (classically activated "M1-like" macrophages) or promoting tissue remodeling and repair (alternatively activated "M2-like" macrophages). These phenotypes are induced by differ…
Cancer is one of the main causes of death worldwide, and the leading type of cancer new cases in 2020 was breast cancer. Triple-negative breast cancer (TNBC), accounts for 10-15% of all breast cancers and is characterized by lack of estrogen, progesterone and human epidermal growth factor receptors expression. It is the most aggressive, and therefore therapies are more intricate. Immune c…
Introduction: Allogeneic hematopoietic stem cell transplantation (HCT) is one of the main treatments for hematological malignancies. HCT provides prolonged disease-free survival for many patients, but relapse remains the most frequent cause of death. Donor lymphocytes infusion (DLI) is used after HCT to treat or prevent disease relapse by boosting the graft versus tumor (GvT) effect, howe…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 14 / 14 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 31 / 31 | All research grants and scholarships |
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