Lucas Simões Machado
CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Zootecnia e Engenharia de Alimentos (FZEA) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Master in Science by the School of Veterinary Medicine and Animal Science, University of São Paulo (FMVZ/USP). During the masters, he had the opportunity to spend 6 months at University of Copenhagen in Professor Hyttel and Professor Freude´s laboratory, funded by BEPE (FAPESP) scholarship . Graduated in the Medicine Veterinary program at the University of São Paulo (USP),Faculty of Animal Science and Food Engineering in Pirassununga - SP. During the veterinary program, he was an exchange student by the Science Without Borders program at the University of Guelph and worked as an intern in the Research Laboratory: Reproductive Health and Biotechnology at the Ontario Veterinary College. He has also worked at the Centre de Recherche en Reproduction animale (CRRA) at the Université de Montréal in Prof. Dr. Lawrence Smith´s lab with the BEPE scholarship (FAPESP). During his undergraduate studies he developed 3 scientific projects, 2 funded by FAPESP and 1 by CNPq. Has experience in molecular biology and cell culture and is interested in neurology, cellular reprogramming, stem cells and induced pluripotent stem cells (iPS). (Source: Lattes Curriculum)
- Induction of cell pluripotency and in vitro differentiation in the porcine model as a translational model, BP.MS
Abstract
In 2006, Takahashi and collaborators reported the induction to pluripotency of somatic cells (induced pluripotent stem cells, iPS). Since then, this technique has much been developed; many animal models have been created opening a new series of opportunities in research. They allow us the creation of models for human genetic diseases, for example, amyotrophic lateral sclerosis, autism, ...
- Imprinting status of H19 and IGF2 genes during reprogramming of induced pluripotent stem cells (IPS) into germinative lineages in cattle, BP.IC
Abstract
The study of embryonic stem cells provides significant advances for both cell therapy and basic sciences. However, difficulties on adequate isolation and maintenance of in vitro cultures, as well as ethical and immunological barriers, are common obstacles in its routine practice. The report of induced pluripotency demonstrated by Kazutoshi Takahashi and Shinya Yamanaka instigated new pr...
- Isolation of cancer stem cells in mammary tumors of female dogs, BP.IC
- Generation and functional characterization of neuronal cells derived from iPSCs from patients with neurodegenerative diseases, BE.EP.MS
Abstract
Induced pluripotent stem cells (iPSCs) are pluripotent cells derived from differentiated cells that have reacquired pluripotency through expression of specific transcription factors. The process is also referred to as cellular reprogramming. This unique method has enabled us to study diseases for which it was challenging to obtain patient samples. Due to the limitations of accessing bra...
- Study of H19 and IGF2 imprinted genes during the reprogramming of induced pluripotent stem cells (IPS) into primordial germ cells-like (PGCLs) in cattle, BE.EP.IC
Abstract
The study of embryonic stem (ES) cells provides significant advances for both cell therapy and basic sciences. However, difficulties in the adequate isolation and maintenance of ES in vitro cultures, as well as ethical and immunological barriers, are common obstacles to a practical application. The development of induced pluripotency by known transcription factors instigates new promisi...
| 3 / 3 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 5 / 5 | All Scholarships |
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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GODOY PIERI, NAIRA CAROLINE; DE SOUZA, ALINE FERNANDA; BOTIGELLI, RAMON CESAR; MACHADO, LUCAS SIMOES; AMBROSIO, CARLOS EDUARDO; MARTINS, DANIELE DOS SANTOS; CESAR DE ANDRADE, ANDRE FURUGEN; MEIRELLES, FLAVIO VIEIRA; HYTTEL, POUL; BRESSAN, FABIANA FERNANDES. Stem cells on regenerative and reproductive science in domestic animals. VETERINARY RESEARCH COMMUNICATIONS, v. 43, n. 1, p. 7-16, FEB 2018. Web of Science Citations: 2. (13/09392-9, 15/26818-5, 12/01060-4, 13/08135-2)