CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Professor Pilli holds BSc (1976) and PhD (1981)degrees from University of Campinas and post-doctoral training at University of California, Berkeley (1982-84). He has been visiting professor at Georg-August Universitat, Gottingen, Germany (1994) and at Warwick University, UK (2005). He is currently professor of Chemistry at University of Campinas working on synthetic chemistry, particularly organic synthesis of natural products and natural product-inspired compounds for biological studies. He has also several patents applications on the synthesis of pharmaceutical active ingredients such as methyl phenidate, tamoxifen, levobupivacine and fluoxetine. He has served the Brazilian Chemical Society as secretary of the division of Organic Chemistry and on the editorial board of Quimica Nova and the Journal of the Brazilian Chemical Society and as head of the Institute of Chemistry and Vice-chancellor for Research at University of Campinas. Professor Pilli has received the Union Carbide Award (1989), the Silver Jubilee Award from the International Foundation for Science, Sweden (1999), the National Medal for Scientific Achievement (2006), the Zeferino Vaz Award from the University of Campinas (2008), the Simão Mathias Award from the Brazilian Chemical Society (2012) and the Teaching Award from University of Campinas (2018). He is a member of the São Paulo Science Academy and Brazilian Academy of Sciences. He has been involved with outreach programs (Chemistry in Action, ScienceArts Program and Brazilian Chemistry Olympiad) and is currently the head of the outreach program of the "Multidisciplinary Center for Obesity and Related Diseases" funded by FAPESP. He currently serves as member of the boards of Fundação Universidade Virtual do Estado de São Paulo (UNIVESP) and Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP) where he is also the deputy president. (Source: Lattes Curriculum)
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This research proposal deals with the synthesis of heterocyclic compounds to be investigated as chemical probes and inhibitors of the neglected kinases LOK/STK10, VRK1 and VRK2 as well as the synthesis of brazilin and its analogues in order to probe their cytotoxic activities against cancer cell lines both in the non-encapsulated and associated with AcDex nanoparticles. The structures of …
The total synthesis of representatives of the Stemona alkaloids is proposed based on a biossynthetic rationale. Our synthetic efforts will be directed to the synthesis of racemic tuberostemospironine, stemolactam R, tuberostemospiroline, croomine and sessilifoliamide J. Our approach is based on the intramolecular tandem vinylogous Mannich cyclization reaction of a silyloxyfuran and an imi…
Mais de 500 proteínas quinases estão presentes no genoma humano, atuando como chaves regulatórias de praticamente todos os processos fisiológicos do organismo humano. As quinases podem ser moduladas através de pequenas moléculas químicas altamente potentes. No entanto, apesar de sua importância e adequação para a descoberta de fármacos, a maioria das pesquisas acadêmicas e farmacêuticas t…
(Only some records are available in English at this moment)
The biological relevance of biomolecules prone to undergo phosphorylation and dephosphorylation processes is associated to their ability to control the biological role of kinase and phosphatase proteins. Several phosphorylated or phosphonylated organic compounds act as inhibitors or chemical probes for the aforementioned enzymes. This research proposal aims the preparation of phosphoryl, …
Chemical probes are important tools for functional study of biomacromolecules. In the context of the development of new drugs, these tools are used in the validation or invalidation of essential therapeutic targets for the progression of diseases. The development of a chemical probe involves structural optimization by Medicinal Chemistry focusing on potency and selectivity optimization, a…
Nontuberculous mycobacteria (NTM) are opportunistic pathogens responsible for pulmonary disease in immunocompromised patients or patients with pre-existing lung conditions such as bronchiectasis, cystic fibrosis or chronic obstructive pulmonary disease. Due to bacterial resistance and inefficient drugs, the incidence and prevalence of pulmonary diseases caused by NTMs have significantly i…
(Only some records are available in English at this moment)
Molecules containing a sulfonyl (-SO2-) functionality are valuable building blocks in organic synthesis, medicinal chemistry, and pharmaceutical industry. Over the last few years, there has been an increasing interest in the development of methods for the synthesis of the sulfonyl moiety by direct incorporation of SO2. This research project aims the preparation of sulfones using an electr…
Neuropsychiatric disorders are a relatively common but very debilitating condition and encompasses conditions such as schizophrenia, bipolar disorders and major depressive disorders. They have a high degree of heritability which can be linked to genetic abnormities in the genetic transcription of the DNA information. The regulatory transcription factors are a very important class of prote…
Natural products have been the major source of inspiration for the development of novel drugs for cancer treatments. In particular, several studies have highlighted the potential of goniothalamin (GTN) and piplartine (PPT), natural products found in plants, for cancer therapy. However, their low water solubility, and significant toxicity towards healthy cells can severely limit their appl…
(Only some records are available in English at this moment)
| 18 / 12 | Completed research grants |
| 67 / 27 | Completed scholarships in Brazil |
| 11 / 11 | Completed scholarships abroad |
| 97 / 51 | All research grants and scholarships |
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