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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach

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Author(s):
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Delabio, Roger [1] ; Rasmussen, Lucas [2] ; Mizumoto, Igor [1] ; Viani, Gustavo-Arruda [1] ; Chen, Elizabeth [3] ; Villares, Joao [3] ; Costa, Isabela-Bazzo [1] ; Turecki, Gustavo [4] ; Linde, Sandra Aparecido [5] ; Smith, Marilia Cardoso [3] ; Payao, Spencer-Luiz [1, 2]
Total Authors: 11
Affiliation:
[1] Fac Med Marilia, Sao Paulo - Brazil
[2] Univ Sagrado Coracao, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Sao Paulo - Brazil
[4] Douglas Hosp, Brain Bank, Montreal, PQ - Canada
[5] Univ Estadual Paulista, Fac Med, Lab NeoGene, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 42, n. 3, p. 757-760, 2014.
Web of Science Citations: 8
Abstract

Presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of amyloid-beta peptides. 150 RNA samples from the entorhinal cortex, auditory cortex and hippocampal regions of individuals with Alzheimer's disease (AD) and controls elderly subjects were analyzed with using real-time rtPCR. There were no differences between groups for PSEN1 expression. PSEN2 was significantly downregulated in the auditory cortex of AD patients when compared to controls and when compared to other brain regions of the patients. Alteration in PSEN2 expression may be a risk factor for AD. (AU)

FAPESP's process: 09/10777-7 - Expression of ribosomal genes and B-amyloid precursor protein in brain and blood samples of patients with Alzheimer's Disease using the Real Time PCR technique
Grantee:Lucas Trevizani Rasmussen
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/15857-9 - Ribosomal gene expression of B-amyloid precursor protein, of presenilin and cytokines in brain and blood samples of Alzheimer's disease patients by Real Time PCR technique
Grantee:Spencer Luiz Marques Payão
Support Opportunities: Regular Research Grants