Synthesis and antimycobacterial activity of new pyrazolate-bridged dinuclear complexes of the type [Pd(mu-L)(N-3)(PPh3)](2) (PPh3 = triphenylphosphine; L = pyrazolates)

Author(s)

da Silva, C. ^[1] ; Ferreira, J. G. ^{[2, 1]} ; Mauro, A. E. ^[1] ; Frem, R. C. G. ^[1] ; Santos, R. H. A. ^[2] ; da Silva, P. B. ^{[1, 3]} ; Pavan, F. R. ^[3] ; Marino, L. B. ^[3] ; Leite, C. Q. F. ^[3] ; Netto, A. V. G. ^[1]

Affiliation

^[1] Univ Estadual Paulista, Inst Quim Araraquara, Araraquara, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[3] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Inorganic Chemistry Communications; v. 48, p. 153-155, OCT 2014.
• Web of Science Citations: 4

Abstract

Binuclear compounds of the type {[}Pd(mu-L)(N-3)(PPh3)](2) [L = pyrazolate (1); 3,5-dimethylpyrazolate (2); 4-iodopyrazolate (3); PPh3 = triphenylphosphine] were synthesized and characterized by elemental analyses, infrared and H-1 and P-31[H-1] NMR spectroscopies. The crystal and molecular structures of the complex {[}Pd(mu-dmPz)(N-3)(PPh3)](2) (2) were determined by single-crystal X-ray diffraction techniques. In vitro antimycobacterial evaluation demonstrated that compound {[}Pd(mu-Pz)(N-3)(PPh3)](2) (1) displayed a MIC of 8.16 mu M, being more active than some commonly used anti-TB drugs and other Pd(II) complexes. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/15486-3 - Pd(II) compounds: synthesis, cytotoxicity, and DNA binding studies
• Grantee: Regina Celia Galvao Frem
• Support Opportunities: Regular Research Grants