Structural features and cytotoxic activities of [Ru(AA-H)(dppb)(bipy)]PF6 complexes

Author(s)

Almeida, Marcio A. P. ^[1] ; do Nascimento, Fabio B. ^[2] ; Graminha, Angelica E. ^[2] ; Ferreira, Antonio G. ^[2] ; Ellena, Javier ^[3] ; Mello, Francyelli M. dos S. ^[4] ; de Lima, Aliny P. ^[4] ; Silveira-Lacerda, Elisangela de P. ^[4] ; Batista, Alzir A. ^[2]

Affiliation

^[1] Univ Fed Maranhao, BR-65080805 Sao Luis, MA - Brazil

^[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[4] Univ & Fed Goias, Inst Ciencias Biol, BR-74001970 Goiania, Go - Brazil

• Document type: Journal article
• Source: Polyhedron; v. 81, p. 735-742, OCT 15 2014.
• Web of Science Citations: 10

Abstract

Amino acid/diphosphine ruthenium complexes, of general formula {[}Ru(AA-H)(dppb)(bipy)PF6 {[}AA = amino acid: glycine (gly), L-alanine (ala), L-tyrosine (tyr), L-methionine (met), L-leucine (leu), L-valine (val), L-serine (ser), L-tryptophan (trp), and L-lysine(lys); dppb = 1,4-bis(diphenylphosphino)butane; bipy = 2,2'-bipyridine], were synthesized and characterized. The X-ray structures of the glycine and leucine complexes showed that the amino acids are coordinated to the metal center through the carboxylate and amine groups. The complexes, except for the glycine ligand, form two different conformational isomers, as suggested by X-ray structure determination of the complex with leucine, and shown by P-31[H-1] NMR analysis. The cyclic and differential pulse voltammograms of the complexes exhibited an oxidation potential (Ru-II/Ru-III) close to 1.0 V, against Ag/AgCl. Toxicity tests against the MDA-MB-231 and DU 145 human tumor cell lines and the Ehrlich mouse cell line indicated a high degree of cytotoxicity for the amino acid complexes. The intrinsic binding constants (K-b) for the amino acid complexes were determined and found to be in the range of 1.40 x 10(4)-1.80 x 10(4) M-1, suggesting weak interactions of the complexes with DNA. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 12/06013-4 - Study of apoptosis gene expression, celular cyclic, DNA repair and oxidative stress in cells of human lang carcinoma treated with complexes with general formula [Ru(AA)(dppb)(bipy)]PF6
• Grantee: Alzir Azevedo Batista
• Support Opportunities: Regular Research Grants