Interaction between the antimicrobial peptide Aure... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interaction between the antimicrobial peptide Aurein 1.2 dimer and mannans

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Author(s):
Lorenzon, Esteban N. [1] ; Piccoli, Julia P. [1] ; Cilli, Eduardo M. [1]
Total Authors: 3
Affiliation:
[1] UNESP Univ Estadual Paulista, Inst Chem, BR-14800060 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Amino Acids; v. 46, n. 11, p. 2627-2631, NOV 2014.
Web of Science Citations: 8
Abstract

We have previously described the structure and the ability of a dimeric analog of the antimicrobial peptide Aurein 1.2 to aggregate Candida albicans. In this study, circular dichroism and fluorescence spectroscopy data showed that this aggregation is related to the interaction between the peptide and mannans, the main component of yeast cell wall. In this context, we propose a model in which dimers interact with the polysaccharide leading to cells aggregation. (AU)

FAPESP's process: 12/15346-7 - Antimicrobial peptides: dimerization effects and encapsulation in NRLb biomembrane
Grantee:Eduardo Maffud Cilli
Support Opportunities: Regular Research Grants