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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Systemic toxic effects during early phases of topical 4-NQO-induced oral carcinogenesis in rats

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Author(s):
Ribeiro Barcessat, Ana Rita [1] ; Huang, Isaac [1] ; Rabelo, Gustavo Davi [2] ; Perillo Rosin, Flavia Cristina [1] ; Valente Ferreira, Luciana Goncalves [1] ; de Cerqueira Luz, Joao Gualberto [3] ; Correa, Luciana [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Dent, Gen Pathol Dept, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Dent, Oral Pathol Dept, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Dent, Oral Surg Dept, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 43, n. 10, p. 770-777, NOV 2014.
Web of Science Citations: 1
Abstract

BackgroundMost studies have demonstrated 4-NQO toxicity to oral epithelium during oral carcinogenesis induction, but systemic toxicity has been poorly addressed. The aim of this study was to describe the systemic effect of 4-NQO topical application during early phases of oral cancer induction. MethodsA 4-NQO propylene glycol ointment was topically applied on the rat tongue three times a week for 16weeks. Local and systemic 4-NQO toxicity was evaluated by body weight gain, hematology, and serum chemistry analyses, histopathology, and proliferating cell nuclear antigen (PCNA) immunohistochemistry. ResultsSignificant reduction in body weight gain and in white blood cell count as well as significant increase in serum ALT and AST was observed after 16weeks of 4-NQO topical application. Focal hepatic lobular necrosis, renal tubular degeneration, and decreased cellularity in the splenic white pulp were also detected. Conclusions4-NQO topical application on the tongue of rats for 16weeks seems to have caused hepatic, renal, and splenic toxicity. Potential systemic toxicity should be considered to monitor for variables that could interfere in topical oral carcinogenesis experiments. (AU)

FAPESP's process: 11/07437-0 - Expression of cellular death markers in premalignant lesions induced in rat tongue and treated with photodynamic therapy
Grantee:Luciana Corrêa
Support Opportunities: Regular Research Grants