Cobalt(III) Complexes with Thiosemicarbazones as Potential anti-Mycobacterium tuberculosis Agents

Author(s)

Oliveira, Carolina G. ^[1] ; Maia, Pedro Ivo da S. ^[2] ; Miyata, Marcelo ^[3] ; Pavan, Fernando R. ^[3] ; Leite, Clarice Q. F. ^[3] ; de Almeida, Eduardo Tonon ^[4] ; Deflon, Victor M. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

^[2] Univ Fed Triangulo Mineiro, Dept Quim, BR-38025440 Uberaba, MG - Brazil

^[3] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil

^[4] Univ Fed Alfenas, Inst Quim, BR-37130000 Alfenas, MG - Brazil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 25, n. 10, p. 1848+, OCT 2014.
• Web of Science Citations: 13

Abstract

Co-III complexes derived from 2-acetylpyridine N(4)-R thiosemicarbazone (Hatc-R, R = alkyl, aryl) have been characterized by elemental analysis, FTIR, UV-Visible and H-1 NMR spectroscopies, cyclic voltammetry (CV), conductimetry measurements and single crystal X-ray diffractometry. The results obtained are consistent with the oxidation of the Co-II center to Co-III upon coordination of the monoanionic N, N, S-tridentate thiosemicarbazone ligands, resulting in octahedral ionic complexes of the type {[}Co(atc-R)(2)]Cl. Electrochemistry studies show two reversible processes referring to the redox couples Co-III/Co-II and Co-II/Co-I which can be modified by the inductive effects of the substituents groups at the N4 position of the ligands. Two Co-III complexes showed satisfactory activity with minimal inhibitory concentration value under 10 mu mol L-1 and one presented quite low cytotoxicity against VERO and J774A.1 cells (IC50), resulting in high selectivity index (SI > 10). (AU)

• FAPESP's process: 13/14957-5 - Research potential against tuberculosis of a new class of furoxan compounds and nanostructured compounds of the ruthenium(II) and copper (II)
• Grantee: Fernando Rogério Pavan
• Support type: Research Grants - Young Investigators Grants
• FAPESP's process: 11/16380-1 - Au, Re and Tc thiosemicarbazones complexes of interest in the development pharmaceuticals or radiopharmaceuticals for diagnostic or therapy
• Grantee: Pedro Ivo da Silva Maia
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 09/54011-8 - Acquisition of a single-crystal X-ray diffractometer for the structural analysis of small molecules and proteins
• Grantee: Victor Marcelo Deflon
• Support type: Multi-user Equipment Program