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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cobalt(III) Complexes with Thiosemicarbazones as Potential anti-Mycobacterium tuberculosis Agents

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Author(s):
Oliveira, Carolina G. [1] ; Maia, Pedro Ivo da S. [2] ; Miyata, Marcelo [3] ; Pavan, Fernando R. [3] ; Leite, Clarice Q. F. [3] ; de Almeida, Eduardo Tonon [4] ; Deflon, Victor M. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
[2] Univ Fed Triangulo Mineiro, Dept Quim, BR-38025440 Uberaba, MG - Brazil
[3] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil
[4] Univ Fed Alfenas, Inst Quim, BR-37130000 Alfenas, MG - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 25, n. 10, p. 1848+, OCT 2014.
Web of Science Citations: 13
Abstract

Co-III complexes derived from 2-acetylpyridine N(4)-R thiosemicarbazone (Hatc-R, R = alkyl, aryl) have been characterized by elemental analysis, FTIR, UV-Visible and H-1 NMR spectroscopies, cyclic voltammetry (CV), conductimetry measurements and single crystal X-ray diffractometry. The results obtained are consistent with the oxidation of the Co-II center to Co-III upon coordination of the monoanionic N, N, S-tridentate thiosemicarbazone ligands, resulting in octahedral ionic complexes of the type {[}Co(atc-R)(2)]Cl. Electrochemistry studies show two reversible processes referring to the redox couples Co-III/Co-II and Co-II/Co-I which can be modified by the inductive effects of the substituents groups at the N4 position of the ligands. Two Co-III complexes showed satisfactory activity with minimal inhibitory concentration value under 10 mu mol L-1 and one presented quite low cytotoxicity against VERO and J774A.1 cells (IC50), resulting in high selectivity index (SI > 10). (AU)

FAPESP's process: 13/14957-5 - Research potential against tuberculosis of a new class of furoxan compounds and nanostructured compounds of the ruthenium(II) and copper (II)
Grantee:Fernando Rogério Pavan
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 11/16380-1 - Au, Re and Tc thiosemicarbazones complexes of interest in the development pharmaceuticals or radiopharmaceuticals for diagnostic or therapy
Grantee:Pedro Ivo da Silva Maia
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 09/54011-8 - Acquisition of a single-crystal X-ray diffractometer for the structural analysis of small molecules and proteins
Grantee:Victor Marcelo Deflon
Support type: Multi-user Equipment Program