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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ultrastructural and biochemical analysis of the effects of alendronate on salivary glands of young rats

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Author(s):
Oliveira, This C. [1] ; Bradaschia-Correa, Vivian [1] ; Castro, Juliana R. [1] ; Simoes, Alyne [1] ; Arana-Chavez, Victor E. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Dent, Dept Biomat & Oral Biol, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 59, n. 12, p. 1307-1311, DEC 2014.
Web of Science Citations: 0
Abstract

Introduction: The bisphosphonates are drugs known by their antiresorptive potency and are widely prescribed for treating and preventing osteoporosis. In the past years the employment of this class of drugs had spread to other pathologies, and it is being prescribed to patients in a wide range of ages. Some adverse effects of bisphosphonate treatment have been highlighted recently, however, little is known about its potential side effects in salivary glands. Methods: Newborn rats received daily doses of 2.5 mg/kg/day of sodium alendronate during 30 days. On the thirtieth day the animals were stimulated with pilocarpine and their parotid and submandibular glands were collected, fixed and embedded for histological and ultrastructural analysis. Some glands were collected for analysis of protein content and amylase activity. Results: At light microscopy, the alendronate-treated animals presented an accumulation of secretion granules in their cytoplasm, which was confirmed by the ultrastructural examination. Biochemical analysis revealed an increase in total protein content and decreased amylase levels of both glands in the alendronate-treated animals in relation to the control. Conclusion: Based on the current findings, alendronate is probably interfering in secretory pathways of parotid and submandibular glands. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/18153-0 - Morphological, ultrastructural and biochemical study of salivary glands of rats treated with sodium alendronate
Grantee:Taís Carvalho de Oliveira
Support Opportunities: Scholarships in Brazil - Scientific Initiation