Scholarship 12/20845-2 - Bioquímica oral, Glândula parótida - BV FAPESP
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Effect of laser on calmodulin concentration of parotid glands of diabetic rats

Grant number: 12/20845-2
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Start date until: January 02, 2013
End date until: March 01, 2013
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Alyne Simões Gonçalves
Grantee:Juliana Rodrigues de Castro
Supervisor: Seunghee Cha
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Institution abroad: University of Florida, Gainesville (UF), United States  
Associated to the scholarship:12/02739-0 - Effect of LPT on lipid accumulation and calmodulin concentration of STZ-induced diabitic rats, BP.IC

Abstract

Diabetes mellitus causes a series of biochemical and histological changes in the salivary glands of streptozotocin-induced diabetic rats. Furthermore, our group has investigated the effect of laser irradiation upon salivary glands and our data demonstrated that this therapy would be helpfull in cases of hypofunction of the salivary glands and xerostomia. However, the action mechanism of this therapy on the glandular tissue is unclear. In this sense, continuing our studies, the present study aims the effect of laser irradiation on calmodulin concentration. For this purpose, 30 Wistar rats will be divided into 3 groups: C0 (control): simulation of irradiation, D0 (diabetic) simulation of irradiation, D20: 20 J/cm2. The diode laser (660 nm), 100 mW of power, will be used in areas corresponding to the parotid and submandibular glands. The rats will be euthanized 24 h after irradiation and salivary glands removed for biochemical (calmodulin concentration) analysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CASTRO, JULIANA R.; DE SOUZA, EUGEN M. N.; PARK, YUN-JONG; DE CAMPOS, LUANA; CHA, SEUNGHEE; ARANA-CHAVEZ, VICTOR E.; NICOLAU, JOSE; SIMOES, ALYNE. Low-power laser irradiation decreases lipid droplet accumulation in the parotid glands of diabetic rats. Journal of Biophotonics, v. 11, n. 4, . (12/20845-2, 11/14013-1, 12/02739-0)

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