Th2 immune responses as a risk factor for focal segmental glomerulosclerosis
| Full text | |
| Author(s): Show less - |
Pereira, Rafael Luiz
[1, 2]
;
Ferreira Felizardo, Raphael Jose
[1]
;
Cenedeze, Marcos Antoino
[1]
;
Hiyane, Meire Ioshie
[2]
;
Bassi, Enio Jose
[1]
;
Amano, Mariane Tami
[1]
;
Taemi Origassa, Clarice Sylvia
[1]
;
Silva, Reinaldo Correia
[3]
;
Aguiar, Cristhiane Favero
[2]
;
Carneiro, Sylvia Mendes
[4]
;
Pesquero, Joao Bosco
[5]
;
Araujo, Ronaldo Carvalho
[5]
;
Keller, Alexandre de Castro
[6]
;
Monteiro, Renato C.
[7]
;
Moura, Ivan Cruz
[7]
;
Pacheco-Silva, Alvaro
[1, 8]
;
Saraiva Camara, Niels Olsen
[1, 2]
Total Authors: 17
|
| Affiliation: | [1] Univ Fed Sao Paulo, Clin & Expt Immunol Lab, Div Nephrol, BR-04023900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Transplantat Immunobiol, BR-05508000 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Translat Med Div, Clin & Expt Immunol Lab, BR-04039002 Sao Paulo - Brazil
[4] Inst Butantan, Lab Cellular Biol, BR-05503900 Sao Paulo - Brazil
[5] Fed Univ Sao Paulo UNIFESP, Dept Biophys, BR-04023062 Sao Paulo - Brazil
[6] Fed Univ Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, BR-04023062 Sao Paulo - Brazil
[7] INSERM, Unite Mixte Rech 699, F-75870 Paris - France
[8] Albert Einstein Hosp, Inst Israelita Ensino & Pesquisa Albert Einst, Renal Transplantat Unit, BR-05521000 Sao Paulo - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Disease Models & Mechanisms; v. 7, n. 6, p. 701-710, JUN 2014. |
| Web of Science Citations: | 6 |
| Abstract | |
Focal and segmental glomerulosclerosis (FSGS) is one of the most important renal diseases related to end-stage renal failure. Bradykinin has been implicated in the pathogenesis of renal inflammation, whereas the role of its receptor 2 (B2RBK; also known as BDKRB2) in FSGS has not been studied. FSGS was induced in wild-type and B2RBK-knockout mice by a single intravenous injection of Adriamycin (ADM). In order to further modulate the kinin receptors, the animals were also treated with the B2RBK antagonist HOE-140 and the B1RBK antagonist DALBK. Here, we show that the blockage of B2RBK with HOE-140 protects mice from the development of FSGS, including podocyte foot process effacement and the re-establishment of slit-diaphragm-related proteins. However, B2RBK-knockout mice were not protected from FSGS. These opposite results were due to B1RBK expression. B1RBK was upregulated after the injection of ADM and this upregulation was exacerbated in B2RBK-knockout animals. Furthermore, treatment with HOE-140 downregulated the B1RBK receptor. The blockage of B1RBK in B2RBK-knockout animals promoted FSGS regression, with a less-inflammatory phenotype. These results indicate a deleterious role of both kinin receptors in an FSGS model and suggest a possible cross-talk between them in the progression of disease. (AU) | |
| FAPESP's process: | 12/05605-5 - Modulation of mTOR signaling pathway in macrophages in the progression of focal and segmental glomerulosclerosis |
| Grantee: | Rafael Luiz Pereira |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 07/07139-3 - The role of heme oxygenase 1 in different renal inflammatory process in experimental animal models |
| Grantee: | Niels Olsen Saraiva Câmara |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches |
| Grantee: | Niels Olsen Saraiva Câmara |
| Support type: | Research Projects - Thematic Grants |