| Full text | |
| Author(s): |
Tamashiro, Leticia Faleiros
[1, 2]
;
Oliveira, Rene D. R.
[1, 2]
;
Oliveira, Rodrigo
[1, 2]
;
Comini Frota, Elizabeth Regina
[3]
;
Donadi, Eduardo Antonio
[1, 2]
;
Del-Ben, Cristina Marta
[4]
;
Teixeira, Antonio Lucio
[3]
;
Louzada-Junior, Paulo
[1, 2]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Div Clin Immunol, BR-048900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Ctr Res Inflammatory Dis, BR-048900 Sao Paulo - Brazil
[3] Univ Fed Minas Gerais, Univ Hosp, Neurol Unit, Minas Gerais - Brazil
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Div Psychiat, BR-048900 Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | RHEUMATOLOGY; v. 53, n. 12, p. 2182-2190, DEC 2014. |
| Web of Science Citations: | 6 |
| Abstract | |
Objective. Brain-derived neurotrophic factor (BDNF) is associated with the pathogenesis of several neuropsychiatric (NP) diseases, but there are few studies involving SLE. The aim of this study was to investigate whether plasma BDNF levels are associated with disease activity in SLE patients with severe NPSLE and non-NPSLE manifestations. Methods. We assessed 131 SLE patients and 24 randomly selected healthy individuals. SLE patients were evaluated in a cross-sectional study allocated according to the presence or not of NP manifestations and disease activity: (i) active NPSLE (n = 40), (ii) inactive NPSLE (n = 26), (iii) active SLE (n = 29) and (iv) inactive SLE (n = 36). In addition, NPSLE patients (n = 40) were evaluated before and after treatment. Disease activity was assessed according to the SLEDAI score. The plasma BDNF was measured by ELISA. Results. BDNF levels were increased in inactive NPSLE when compared with active SLE and controls (P < 0.0001). We observed similar findings in inactive SLE when compared with active SLE (P < 0.0001). In addition, we found an inverse correlation between plasma BDNF levels and the SLEDAI (r = -0.54, P < 0.0001) and a positive correlation with complement levels. We also observed an increase in BDNF levels in parallel with the improvement in NP symptoms. Conclusion. Plasma BDNF level is increased in SLE patients and this increase is independent of the occurrence of NP manifestations. In addition, plasma BDNF levels increased with control of SLE activity, which points to the potential use of BDNF as a biomarker of response to treatment. (AU) | |
| FAPESP's process: | 13/08216-2 - CRID - Center for Research in Inflammatory Diseases |
| Grantee: | Fernando de Queiroz Cunha |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 11/19670-0 - Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis |
| Grantee: | Fernando de Queiroz Cunha |
| Support Opportunities: | Research Projects - Thematic Grants |