Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L.) infantum chagasi-infection

Author(s)

do Rego Lima, Luciana Vieira ^[1] ; Santos Ramos, Patricia Karla ^[1] ; Campos, Marliane Batista ^[1] ; dos Santos, Thiago Vasconcelos ^[1] ; de Castro Gomes, Claudia Maria ^[2] ; Laurenti, Marcia Dalastra ^[2] ; Pereira Corbett, Carlos Eduardo ^[2] ; Silveira, Fernando Tobias ^{[3, 1]}

Affiliation

^[1] Minist Hlth, Evandro Chagas Inst, Dept Parasitol Dept, Ananindeua, Para - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil

^[3] Fed Univ Para, BR-66059 Belem, Para - Brazil

• Document type: Journal article
• Source: PATHOGENS AND GLOBAL HEALTH; v. 108, n. 8, p. 381-384, DEC 2014.
• Web of Science Citations: 3

Abstract

American visceral leishmaniasis (AVL) is an infectious disease, often with long-duration evolution, caused by Leishmania (L.) infantum chagasi. However, although the disease is considered the major clinical manifestation of the link between L. (L.) i. chagasi and the human immune response, we have recently identified five clinical-immunological profiles of infection in the Brazilian Amazon: three asymptomatic (Asymptomatic Infection - AI, Sub-clinical Resistant Infection - SRI, and Indeterminate Initial Infection III), and two symptomatic ones {[}Symptomatic Infection - SI (=AVL) and Sub-clinical Oligosymptomatic Infection - SOI]. We confirm here the preclinical diagnosis of AVL through the IgM-antibody response in a case of an early infection (profile III) that evolved to the full disease after 6 weeks.` (AU)

• FAPESP's process: 06/56319-1 - Leishmaniasis in Brazil: clinical and immunopathogenetic aspects of the human and experimental disease
• Grantee: Carlos Eduardo Pereira Corbett
• Support Opportunities: Research Projects - Thematic Grants