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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Upregulated genes at 2q24 gains as candidate oncogenes in hepatoblastomas

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Author(s):
Rodrigues, Tatiane Cristina [1] ; Fidalgo, Felipe [2] ; Lima da Costa, Cecilia Maria [3] ; Ferreira, Elisa Napolitano [2] ; da Cunha, Isabela Werneck [4] ; Carraro, Dirce Maria [2] ; Victorino Krepischi, Ana Cristina [1, 2] ; Rosenberg, Carla [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo - Brazil
[2] AC Camargo Canc Ctr, Int Ctr Res, Sao Paulo - Brazil
[3] AC Camargo Canc Ctr, Dept Pediat Oncol, Sao Paulo - Brazil
[4] AC Camargo Canc Ctr, Dept Pathol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: FUTURE ONCOLOGY; v. 10, n. 15, p. 2449-2457, 2014.
Web of Science Citations: 5
Abstract

Aim: Cytogenetic data of hepatoblastomas, a rare embryonal tumor of the liver, mostly consist of descriptions of whole-chromosome aneuploidies and large chromosome alterations. High-resolution cytogenetics may provide clues to hepatoblastoma tumorigenesis and indicate markers with clinical significance. Patients \& methods: We used array-CGH (180K) to screen for genomic imbalances in nine hepatoblastomas. Additionally, we investigated the expression pattern of selected genes exhibiting copy number changes. Results: Analysis showed mainly whole-chromosome or chromosome-arm aneuploidies, but some focal aberrations were also mapped. Expression analysis of 48 genes mapped at one 10 Mb amplification at 2q24 revealed upregulation of DAPL1, ERMN, GALNT5, SCN1A and SCN3A in the set of tumors compared with differentiated livers. Conclusion: These genes appear as candidates for hepatoblastoma tumorigenesis. (AU)

FAPESP's process: 06/00054-0 - Gene expression analysis of kidney and liver development stages and their implications in embryonic tumors
Grantee:Dirce Maria Carraro
Support type: Regular Research Grants
FAPESP's process: 11/24007-9 - Genetic and epigenetic anomalies in the childhood tumor hepatoblastoma
Grantee:Tatiane Cristina Rodrigues
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 09/00898-1 - Submicroscopic genomic imbalances associated with specific congenital abnormalities and mental deficiency phenotypes
Grantee:Carla Rosenberg
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center
Grantee:Mayana Zatz
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC