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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Odor Cues Released by Ehrlich Tumor-Bearing Mice Are Aversive and Induce Psychological Stress

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Author(s):
Alves, Glaucie Jussilane [1] ; Palermo-Neto, Joao [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med, Lab Appl Pharmacol & Toxicol, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: NEUROIMMUNOMODULATION; v. 22, n. 3, p. 121-129, 2015.
Web of Science Citations: 2
Abstract

Background/Aims: This study aimed to verify if odor cues released by Ehrlich tumor-bearing mice are aversive and stressful. Methods: Female mice were divided into a control group and an experimental group. One animal of each experimental pair of mice was inoculated with 5 x 10 6 Ehrlich tumor cells intraperitoneally; the other animal was kept undisturbed and was referred to as a CSP (companion of sick partner). One mouse of each control pair was treated intraperitoneally with 0.9% NaCl (1 mg/kg); the other animal (CHP, companion of healthy partner) was kept undisturbed. Results: It was shown that, in relation to CHP, CSP mice (1) spent less time within the companion zone in a T-maze place preference test, (2) had increased levels of social interaction, (3) had increased levels of plasmatic adrenaline and noradrenaline and (4) displayed no changes in serum corticosterone levels before and after an immobilization stress challenge. It was also shown that (5) cohabitation with 2 tumor-bearing mice was more effective in decreasing neutrophil oxidative burst than cohabitation with 1 sick partner and (6) the presence of a healthy conspecific within the cage of the tumor-injected/CSP pair abrogated the effects of cohabitation on neutrophil activity. These results show that odor cues released by Ehrlich tumor-injected mice are aversive and induce psychological stress. Conclusion: We postulate that the aversive response induced by the chemosignals released by Ehrlich tumor- injected animals activates the sympathetic nervous system and causes the neuroimmunal changes that occur in the mice cohabiting with the sick mice. (C) 2014 S. Karger AG, Basel (AU)

FAPESP's process: 09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships
Grantee:João Palermo Neto
Support Opportunities: Research Projects - Thematic Grants