Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome

Author(s)

Chielli Pedroso, Daiana Cristina ^[1] ; Miranda-Furtado, Cristiana Libardi ^[1] ; Kogure, Gislaine Satyko ^[1] ; Meola, Juliana ^[1] ; Okuka, Maja ^[2] ; Silva, Celso ^[3] ; Calado, Rodrigo T. ^[4] ; Ferriani, Rui Alberto ^[1] ; Keefe, David L. ^[5] ; dos Reis, Rosana Maria ^[1]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Obstet & Gynecol, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ S Florida, Coll Med, Dept Obstet & Gynecol, Tampa, FL - USA

^[3] Ctr Reprod Med, Orlando, FL - USA

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil

^[5] NYU, Dept Obstet & Gynecol, Langone Med Ctr, New York, NY 10016 - USA

• Document type: Journal article
• Source: Fertility and Sterility; v. 103, n. 2, p. 542-547, FEB 2015.
• Web of Science Citations: 11

Abstract

Objective: To analyze whether leukocyte telomere length (LTL) is impaired in women with polycystic ovary syndrome (PCOS). Design: Case-control study. Setting: Hospital. Patient(s): A total of 274 women, including 150 patients with PCOS and 124 controls. Intervention(s): None. Main Outcome Measure(s): Body mass index (BMI), waist circumference, systemic arterial pressure, lipid profile, E-2, LH, T, androstenedione, PRL, TSH, sex hormone-binding globulin, C-reactive protein (CRP), homocysteine, free androgen index, and the homeostatic model of insulin sensitivity (HOMA-IR) index were analyzed. The LTL evaluation was measured by quantitative polymerase chain reaction. Result(s): The PCOS group had higher values for weight, BMI, waist circumference, systolic arterial pressure, triglycerides, LH, T, insulin, CRP, free androgen index, and HOMA-IR compared with the control group. Sex hormone-binding globulin and E-2 levels were lower in the PCOS group than in the control group. The LTL did not differ between groups. Age, BMI, and HOMA-IR had no significant effect on LTL. The inflammatory biomarkers CRP and homocysteine were negatively correlated with LTL in patients with PCOS. Conclusion(s): Our results showed no differences in LTL between patients with PCOS and controls, but CRP and homocysteine biomarkers negatively correlated with LTL in the PCOS group. (C) 2015 by American Society for Reproductive Medicine. (AU)

• FAPESP's process: 10/08800-8 - Effects of periodized resisted physical exercise in women with hyperandrogenic anovulation
• Grantee: Rosana Maria dos Reis
• Support Opportunities: Regular Research Grants