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Effects of periodized resisted physical exercise in women with hyperandrogenic anovulation

Grant number: 10/08800-8
Support type:Regular Research Grants
Duration: November 01, 2010 - April 30, 2013
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Rosana Maria dos Reis
Grantee:Rosana Maria dos Reis
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Carla Barbosa Nonino ; Cristine Homsi Jorge Ferreira ; Fabiene Karine Picchi Ramos ; Flávia Ignácio Antônio Vassimon ; Gislaine Satyko Kogure ; Rui Alberto Ferriani ; Wellington de Paula Martins

Abstract

Polycystic Ovary Syndrome (PCO) is an endocrinopathy commonly occurring in women of reproductive age, characterized by menstrual irregularity, chronic anovulation and hyperandrogenism. In addition to the reproductive disorders, other health risks are associated with this syndrome due to metabolic changes. About 50% of women with PCO are obese or overweight.Preventive and prophylactic measures such as changes in life style mainly related to weight reduction, practice of regular physical activity, re-education of eating habits and/or dietary orientation should be considered as the basis of treatment of metabolic disorders, with positive and non-pharmacological effects on the treatment of PCO.The practice of resisted exercise has become a popular and important component of the program of physical conditioning for women, being essential as a factor for a healthy life, increasing basal metabolism and promoting an increase in lean mass. The regular practice of physical exercises together with nutritional counseling has been recommended as one of the first-line and low-cost strategies for the treatment of obesity/overweight, hyperandrogenism and infertility in women with PCO. On this basis, the objective of the present study is to analyze the body composition, muscle strength, metabolic changes and telomere size before and after the practice of resisted physical exercises in women with PCO. Women with normal body mass index, overweight or type I obese (BMI <35) will be included, with the study group consisting of 60 women with PCO and the control group consisting of women with ovulatory menstrual cycles. A periodized training preceded by a process of adaptation to physical exams and physical examinations and by a maximal strength test of 1 RM will be used for the program of resisted exercises for the determination of the initial overloads and for later comparisons after a proposed intervention of 4 months. Plasma determinations of Testosterone, SDHEA, 17 OHP, SHBG, and C Reactive Protein will be performed, together with the determination of lipid profile, glucose and basal insulin and leucocytes telomere length measurements will be analyzed before and after 4 months intervention. Body Composition will also be evaluated, with ultrasound exams, electric Bioimpedance and Dexa. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GISLAINE SATYKO KOGURE; RAFAEL COSTA SILVA; VICTOR BARBOSA RIBEIRO; MARIA CÉLIA MENDES; RAFAEL MENEZES-REIS; RUI ALBERTO FERRIANI; CRISTIANA LIBARDI MIRANDA FURTADO; ROSANA MARIA DOS REIS. Concordance in prediction body fat percentage of Brazilian women in reproductive age between different methods of evaluation of skinfolds thickness. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 64, n. 3, p. 257-268, Jun. 2020.
KOGURE, GISLAINE S.; MIRANDA-FURTADO, CRISTIANA L.; PEDROSO, DAIANA C. C.; RIBEIRO, VICTOR B.; EIRAS, MATHEUS C.; SILVA, RAFAEL C.; CAETANO, LISANDRA C.; FERRIANI, RUI A.; CALADO, RODRIGO T.; DOS REIS, ROSANA M. Effects of Progressive Resistance Training on Obesity Indices in Polycystic Ovary Syndrome and the Relationship With Telomere Length. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 16, n. 8, p. 601-607, AUG 2019. Web of Science Citations: 0.
GIELEN, MARIJ; HAGEMAN, GEJA J.; ANTONIOU, EVANGELIA E.; NORDFJALL, KATARINA; MANGINO, MASSIMO; BALASUBRAMANYAM, MUTHUSWAMY; DE MEYER, TIM; HENDRICKS, AUDREY E.; GILTAY, ERIK J.; HUNT, STEVEN C.; NETTLETON, JENNIFER A.; SALPEA, KLELIA D.; DIAZ, VANESSA A.; FARZANEH-FAR, RAMIN; ATZMON, GIL; HARRIS, SARAH E.; HOU, LIFANG; GILLEY, DAVID; HOVATTA, IIRIS; KARK, JEREMY D.; NASSAR, HISHAM; KURZ, DAVID J.; MATHER, KAREN A.; WILLEIT, PETER; ZHENG, YUN-LING; PAVANELLO, SOFIA; DEMERATH, ELLEN W.; RODE, LINE; BUNOUT, DANIEL; STEPTOE, ANDREW; BOARDMAN, LISA; MARTI, AMELIA; NEEDHAM, BELINDA; ZHENG, WEI; RAMSEY-GOLDMAN, ROSALIND; PELLATT, ANDREW J.; KAPRIO, JAAKKO; HOFMANN, JONATHAN N.; GIEGER, CHRISTIAN; PAOLISSO, GIUSEPPE; HJELMBORG, JACOB B. H.; MIRABELLO, LISA; SEEMAN, TERESA; WONG, JASON; VAN DER HARST, PIM; BROER, LINDA; KRONENBERG, FLORIAN; KOLLERITS, BARBARA; STRANDBERG, TIMO; EISENBERG, DAN T. A.; DUGGAN, CATHERINE; VERHOEVEN, JOSINE E.; SCHAAKXS, ROXANNE; ZANNOLLI, RAFFAELA; DOS REIS, ROSANA M. R.; CHARCHAR, FADI J.; TOMASZEWSKI, MACIEJ; MONS, UTE; DEMUTH, ILJA; MOLLI, ANDREA ELENA IGLESIAS; CHENG, GUO; KRASNIENKOV, DMYTRO; D'ANTONO, BIANCA; KASIELSKI, MAREK; MCDONNELL, BARRY J.; EBSTEIN, RICHARD PAUL; SUNDQUIST, KRISTINA; PARE, GUILLAUME; CHONG, MICHAEL; ZEEGERS, MAURICE P.; GROUP, TELOMAAS. Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 108, n. 3, p. 453-475, SEP 2018. Web of Science Citations: 10.
KOGURE, GISLAINE S.; SILVA, RAFAEL C.; MIRANDA-FURTADO, CRISTIANA L.; RIBEIRO, VICTOR B.; PEDROSO, DAIANA C. C.; MELO, ANDERSON S.; FERRIANI, RUI A.; DOS REIS, ROSANA MARIA. HYPERANDROGENISM ENHANCES MUSCLE STRENGTH AFTER PROGRESSIVE RESISTANCE TRAINING, INDEPENDENT OF BODY COMPOSITION, IN WOMEN WITH POLYCYSTIC OVARY SYNDROME. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 32, n. 9, p. 2642-2651, SEP 2018. Web of Science Citations: 1.
PICCHI RAMOS, FABIENE K.; DA SILVA LARA, LUCIA ALVES; KOGURE, GISLAINE SATYKO; SILVA, RAFAEL COSTA; FERRIANI, RUI ALBERTO; SILVA DE SA, MARCOS FELIPE; DOS REIS, ROSANA MARIA. Quality of Life in Women with Polycystic Ovary Syndrome after a Program of Resistance Exercise Training. Revista Brasileira de Ginecologia e Obstetrícia, v. 38, n. 7, p. 340-347, JUL 2016. Web of Science Citations: 3.
KOGURE, GISLAINE SATYKO; MIRANDA-FURTADO, CRISTIANA LIBARDI; SILVA, RAFAEL COSTA; MELO, ANDERSON SANCHES; FERRIANI, RUI ALBERTO; SILVA DE SA, MARCOS FELIPE; DOS REIS, ROSANA MARIA. Resistance Exercise Impacts Lean Muscle Mass in Women with Polycystic Ovary Syndrome. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 4, p. 589-598, APR 2016. Web of Science Citations: 15.
CHIELLI PEDROSO, DAIANA CRISTINA; MIRANDA-FURTADO, CRISTIANA LIBARDI; KOGURE, GISLAINE SATYKO; MEOLA, JULIANA; OKUKA, MAJA; SILVA, CELSO; CALADO, RODRIGO T.; FERRIANI, RUI ALBERTO; KEEFE, DAVID L.; DOS REIS, ROSANA MARIA. Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome. Fertility and Sterility, v. 103, n. 2, p. 542-547, FEB 2015. Web of Science Citations: 11.

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