EFFECTS OF PERIODIZED RESISTED PHYSICAL EXERCISE IN WOMEN WITH HYPERANDROGENIC ANOVULATION

• Grant number: 10/03948-7
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): August 01, 2010
• Effective date (End): April 30, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Rosana Maria dos Reis
• Grantee: Gislaine Satyko Kogure
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Micropolycystic Ovary Syndrome (POS) is an endocrinopathy commonly occurring in women of reproductive age, characterized by menstrual irregularity, chronic anovulation and hyperandrogenism. In addition to the reproductive disorders, other health risks are associated with this syndrome due to metabolic changes. About 50% of women with POS are obese or overweight.Preventive and prophylactic measures such as changes in life style mainly related to weight reduction, practice of regular physical activity, re-education of eating habits and/or dietary orientation should be considered as the basis of treatment of metabolic disorders, with positive and non-pharmacological effects on the treatment of POS.The practice of resisted exercise has become a popular and important component of the program of physical conditioning for women, being essential as a factor for a healthy life, increasing basal metabolism and promoting an increase in lean mass This positive induction of body composition increases the level of conditioning, with benefits for women with hyperandrogenic anovulation.Objective: The regular practice of physical exercises together with nutritional counseling has been recommended as one of the first-line and low-cost strategies for the treatment of obesity/overweight, hyperandrogenism and infertility in women with POS. On this basis, the objective of the present study is to analyze the body composition, muscle strength, metabolic changes and telomere size before and after the practice of resisted physical exercises in women with POS. Patients and Methodology: Sixty women with normal body mass índex or overweight will be included, with the study group consisting of 60 women with POS and the control group consisting of women with ovulatory menstrual cycles. A periodized training preceded by physical examinations and by a maximal strength test of 1 RM will be used for the program of resisted exercises for the determination of the initial overloads and for later comparisons after a proposed intervention of 3 months. Plasma determinations of Testosterone, SDHEA, 17 OHP, SHBG, and C Reactive Protein will be performed, together with the determination of lipid profile, glucose and basal insulin and Telomere measurements. Body Composition will also be evaluated, with ultrasound exams, electric Bioimpedance and Dexa. Patients and controls will be submitted to maximal force tests of 1 RM preceded by a process of adaptation to physical exams and will also receive nutritional counseling.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GISLAINE SATYKO KOGURE; RAFAEL COSTA SILVA; VICTOR BARBOSA RIBEIRO; MARIA CÉLIA MENDES; RAFAEL MENEZES-REIS; RUI ALBERTO FERRIANI; CRISTIANA LIBARDI MIRANDA FURTADO; ROSANA MARIA DOS REIS. Concordance in prediction body fat percentage of Brazilian women in reproductive age between different methods of evaluation of skinfolds thickness. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 64, n. 3, p. 257-268, 2020-06-12. (10/08800-8, 10/03948-7)