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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effect of menopause on objective sleep parameters: Data from an epidemiologic study in Sao Paulo, Brazil

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Author(s):
Hachul, Helena [1, 2, 3] ; Frange, Cristina [1] ; Bezerra, Andreia Gomes [1] ; Hirotsu, Camila [1] ; Pires, Gabriel Natan [1] ; Andersen, Monica Levy [1] ; Bittencourt, Lia [1] ; Tufik, Sergio [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil
[2] Casa Saude Santa Marcelina, Dept Ginecol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Ginecol, BR-04024002 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MATURITAS; v. 80, n. 2, p. 170-178, FEB 2015.
Web of Science Citations: 19
Abstract

Objective: Our objective was to investigate the influence of menopausal status on sleep patterns in a representative sample of women from Sao Paulo, Brazil. Study design: A population-based survey with a probabilistic three-stage cluster sample of the city of Sao Paulo was used to represent the local population according to gender, age (20-80 years) and socioeconomic status. Main outcome measures: The female participants answered a sleep questionnaire, underwent polysomnographic recording and allowed their hormone levels to be measured. They also completed a gynecological questionnaire for classification of the reproductive aging stages: premenopausal or reproductive, perimenopausal or menopausal transition, and postmenopausal, defined as being after 12 months of amenorrhea. Women were allocated into early (the first 5 years after menopause) and late (after the first 5 years) stages. Results: A total of 535 women were included in this study: 339 were premenopausal, 53 were early postmenopausal, 118 were late postmenopausal and 25 were using hormone therapy or isoflavone compounds. Our main findings were that women in postmenopause spent more time in N3 sleep, had a higher apnea-hypopnea index (AHI) and lower Sa02 compared with premenopausal women after an analysis adjusted for confounding factors. We found no significant differences between early and late postmenopausal women-in the adjusted analysis. Conclusion: Our results indicate menopause itself exerts a modest, but important influence on objective sleep patterns, independent of age, in particular on AHI and Sa02. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 14/15259-2 - Epidemiology of sleep in the city of São Paulo: follow-up of volunteers from the population-based study EPISONO
Grantee:Camila Hirotsu
Support Opportunities: Scholarships in Brazil - Post-Doctoral