Carmona, Rafaela C.
Wendler, Edison P.
Sakae, George H.
Comasseto, Joao V.
Dos Santos, Alcindo A.
Total Authors: 5
 Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo - Brazil
 Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP - Brazil
Total Affiliations: 2
Journal of the Brazilian Chemical Society;
Web of Science Citations:
A number of aldehydes, alkynols and benzylamines were submitted to A(3)-coupling reaction, under CuCl catalysis, giving strategically functionalized hydroxy-propargylamines. The procedure allows the use of alkyl as well as aryl aldehydes. Representative substrates were converted into five- and six-membered cyclic alkaloids by sequential one-pot N-debenzylation/triple bond reduction promoted by Pd, followed by a Mitsunobu-type cyclization. (AU)