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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Saturated Fatty Acids Modulate Autophagy's Proteins in the Hypothalamus

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Portovedo, Mariana [1, 2] ; Ignacio-Souza, Leticia M. [3] ; Bombassaro, Bruna [1] ; Coope, Andressa [1] ; Reginato, Andressa [1, 2] ; Razolli, Daniela S. [1] ; Torsoni, Marcio A. [1, 2] ; Torsoni, Adriana S. [1, 2] ; Leal, Raquel F. [1] ; Velloso, Licio A. [1] ; Milanski, Marciane [1, 2]
Total Authors: 11
[1] Univ Estadual Campinas, UNICAMP, Obes & Comorbid Res Ctr, Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Fac Sci Appl, Limeira - Brazil
[3] Univ Fed Mato Grosso, Fac Nutr, Cuiaba - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PLoS One; v. 10, n. 3 MAR 18 2015.
Web of Science Citations: 23

Autophagy is an important process that regulates cellular homeostasis by degrading dysfunctional proteins, organelles and lipids. In this study, the hypothesis that obesity could lead to impairment in hypothalamic autophagy in mice was evaluated by examining the hypothalamic distribution and content of autophagic proteins in animal with obesity induced by 8 or 16 weeks high fat diet to induce obesity and in response to intracerebroventricular injections of palmitic acid. The results showed that chronic exposure to a high fat diet leads to an increased expression of inflammatory markers and downregulation of autophagic proteins. In obese mice, autophagic induction leads to the downregulation of proteins, such as JNK and Bax, which are involved in the stress pathways. In neuron cell-line, palmitate has a direct effect on autophagy even without inflammatory activity. Understanding the cellular and molecular bases of overnutrition is essential for identifying new diagnostic and therapeutic targets for obesity. (AU)

FAPESP's process: 11/14565-4 - Characterization of autophagy in the hypothalamus of different animal models of obesity
Grantee:Mariana Portovedo de Oliveira Araújo
Support Opportunities: Scholarships in Brazil - Master