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Characterization of autophagy in the hypothalamus of different animal models of obesity

Grant number: 11/14565-4
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Marciane Milanski Ferreira
Grantee:Mariana Portovedo de Oliveira Araújo
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil

Abstract

Obesity and type 2 diabetes are associated with activation of signaling pathways and increased inflammatory cytokine production. In turn, hypothalamic inflammation is associated with a lack of control of mechanisms of hunger and thermogenesis and consequently, with the development of obesity. Long chain saturated fatty acids leads to the activation of TLR4 signaling, ER stress and resistance to leptin in the hypothalamus, which are important pathways leading to hypothalamic inflammation. Autophagy is a cellular process in which proteins and organelles are degraded by lysosomal proteases and in the CNS is important for neuronal homeostasis and protein quality control and is closely attached to the immune system and inflammation. Alterations in the process of autophagy is associated with inflammation, type 2 diabetes and obesity, and in central nervous system with neurodegenerative diseases. Studies shows that increased inflammatory mediators may compromise neuronal homeostasis by negatively regulate the degradation and recycling of neuronal protein aggregates by autophagy inhibition. In this context, the objective of this work is to study this important pathway of cellular homeostasis in the hypothalamus of different animal models of obesity.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PORTOVEDO, MARIANA; IGNACIO-SOUZA, LETICIA M.; BOMBASSARO, BRUNA; COOPE, ANDRESSA; REGINATO, ANDRESSA; RAZOLLI, DANIELA S.; TORSONI, MARCIO A.; TORSONI, ADRIANA S.; LEAL, RAQUEL F.; VELLOSO, LICIO A.; MILANSKI, MARCIANE. Saturated Fatty Acids Modulate Autophagy's Proteins in the Hypothalamus. PLoS One, v. 10, n. 3 MAR 18 2015. Web of Science Citations: 23.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ARAÚJO, Mariana Portovedo de Oliveira. Modulation of hypothalamic autophagy in hypothalamus of mice fed with high-fat diet. 2013. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas.

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