| Full text | |
| Author(s): Show less - |
Pinto, Meri Emili F.
[1]
;
Batista, Jr., Joao M.
[2, 3, 1]
;
Koehbach, Johannes
[4, 5]
;
Gaur, Pratibha
[6]
;
Sharma, Abhinay
[6]
;
Nakabashi, Myna
[6]
;
Cilli, Eduardo Maffud
[1]
;
Giesel, Guilherme M.
[7]
;
Verli, Hugo
[7]
;
Gruber, Christian W.
[4]
;
Blanch, Ewan W.
[2, 3]
;
Tavares, Joseam F.
[8]
;
da Silva, Marcelo S.
[8]
;
Garcia, Celia R. S.
[6]
;
Bolzani, Vanderlan S.
[1]
Total Authors: 15
|
| Affiliation: | [1] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Sao Paulo - Brazil
[2] Univ Manchester, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs - England
[3] Univ Manchester, Fac Life Sci, Manchester M1 7DN, Lancs - England
[4] Med Univ Vienna, Ctr Physiol & Pharmacol, A-1090 Vienna - Austria
[5] Univ Queensland, Sch Biomed Sci, St Lucia, Qld 4072 - Australia
[6] Univ Sao Paulo, Inst Biosci, Dept Physiol, BR-05508900 Sao Paulo - Brazil
[7] Univ Fed Rio Grande do Sul, Ctr Biotechnol, BR-91500970 Porto Alegre, RS - Brazil
[8] Fed Univ Paraiba UFPB, Lab Pharmaceut Technol, BR-58051970 Joao Pessoa, Paraiba - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 78, n. 3, p. 374-380, MAR 2015. |
| Web of Science Citations: | 10 |
| Abstract | |
A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 mu M) against the Plasmodium falciparum strain 3D7. (AU) | |
| FAPESP's process: | 11/22339-4 - Chiroptical methods for the characterization of micro- and macromolecules from natural sources |
| Grantee: | João Marcos Batista Junior |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery |
| Grantee: | Glaucius Oliva |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 12/13739-1 - Vibrational optical activity as a probe to molecular chirality |
| Grantee: | João Marcos Batista Junior |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |