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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ribifolin, an Orbitide from Jatropha ribifolia, and Its Potential Antimalarial Activity

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Author(s):
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Pinto, Meri Emili F. [1] ; Batista, Jr., Joao M. [2, 3, 1] ; Koehbach, Johannes [4, 5] ; Gaur, Pratibha [6] ; Sharma, Abhinay [6] ; Nakabashi, Myna [6] ; Cilli, Eduardo Maffud [1] ; Giesel, Guilherme M. [7] ; Verli, Hugo [7] ; Gruber, Christian W. [4] ; Blanch, Ewan W. [2, 3] ; Tavares, Joseam F. [8] ; da Silva, Marcelo S. [8] ; Garcia, Celia R. S. [6] ; Bolzani, Vanderlan S. [1]
Total Authors: 15
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Sao Paulo - Brazil
[2] Univ Manchester, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs - England
[3] Univ Manchester, Fac Life Sci, Manchester M1 7DN, Lancs - England
[4] Med Univ Vienna, Ctr Physiol & Pharmacol, A-1090 Vienna - Austria
[5] Univ Queensland, Sch Biomed Sci, St Lucia, Qld 4072 - Australia
[6] Univ Sao Paulo, Inst Biosci, Dept Physiol, BR-05508900 Sao Paulo - Brazil
[7] Univ Fed Rio Grande do Sul, Ctr Biotechnol, BR-91500970 Porto Alegre, RS - Brazil
[8] Fed Univ Paraiba UFPB, Lab Pharmaceut Technol, BR-58051970 Joao Pessoa, Paraiba - Brazil
Total Affiliations: 8
Document type: Journal article
Source: Journal of Natural Products; v. 78, n. 3, p. 374-380, MAR 2015.
Web of Science Citations: 10
Abstract

A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 mu M) against the Plasmodium falciparum strain 3D7. (AU)

FAPESP's process: 11/22339-4 - Chiroptical methods for the characterization of micro- and macromolecules from natural sources
Grantee:João Marcos Batista Junior
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/13739-1 - Vibrational optical activity as a probe to molecular chirality
Grantee:João Marcos Batista Junior
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor