High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results

Author(s):Show less -

Salum, Giovanni Abrahao ^{[1, 2]} ; Gadelha, Ary ^{[3, 2]} ; Pan, Pedro Mario ^{[3, 2]} ; Moriyama, Tais Silveira ^{[3, 4, 2]} ; Graeff-Martins, Ana Soledade ^{[4, 2]} ; Tamanaha, Ana Carina ^{[3, 2]} ; Alvarenga, Pedro ^{[4, 2]} ; Krieger, Fernanda Valle ^{[4, 2]} ; Fleitlich-Bilyk, Bacy ^{[4, 2]} ; Jackowski, Andrea ^{[3, 2]} ; Sato, Joao Ricardo ^{[2, 5]} ; Brietzke, Elisa ^{[3, 2]} ; Polanczyk, Guilherme Vanoni ^{[4, 2]} ; Brentani, Helena ^{[4, 2]} ; Mari, Jair de Jesus ^{[3, 2]} ; Do Rosario, Maria Conceicao ^{[3, 2]} ; Manfro, Gisele Gus ^{[1, 2]} ; Bressan, Rodrigo Affonseca ^{[3, 2]} ; Mercadante, Marcos Tomanik ^[2] ; Miguel, Euripedes Constantino ^{[4, 2]} ; Rohde, Luis Augusto ^{[1, 4, 2]}

Affiliation

^[1] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS - Brazil

^[2] Natl Inst Dev Psychiat Children & Adolescents INC, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Sao Paulo - Brazil

^[5] Fed Univ ABC, Math & Stat Inst, Santo Andre - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH; v. 24, n. 1, p. 58-73, MAR 2015.
• Web of Science Citations: 52

Abstract

The objective of this study is to present the rationale, methods, design and preliminary results from the High Risk Cohort Study for the Development of Childhood Psychiatric Disorders. We describe the sample selection and the components of each phases of the study, its instruments, tasks and procedures. Preliminary results are limited to the baseline phase and encompass: (i) the efficacy of the oversampling procedure used to increase the frequency of both child and family psychopathology; (ii) interrater reliability and (iii) the role of differential participation rate. A total of 9937 children from 57 schools participated in the screening procedures. From those 2512 (random =958; high risk =1554) were further evaluated with diagnostic instruments. The prevalence of any child mental disorder in the random strata and high-risk strata was 19.9% and 29.7%. The oversampling procedure was successful in selecting a sample with higher family rates of any mental disorders according to diagnostic instruments. Interrater reliability (kappa) for the main diagnostic instrument range from 0.72 (hyperkinetic disorders) to 0.84 (emotional disorders). The screening instrument was successful in selecting a sub-sample with high risk for developing mental disorders. This study may help advance the field of child psychiatry and ultimately provide useful clinical information. Copyright (c) 2014 John Wiley \& Sons, Ltd. (AU)

• FAPESP's process: 08/57896-8 - National Institute for Developmental Psychiatry
• Grantee: Eurípedes Constantino Miguel Filho
• Support Opportunities: Research Projects - Thematic Grants