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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oxygen transfer in different pneumatic bioreactors containing viscous Newtonian fluids

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Author(s):
Mendes, Caroline E. [1] ; Badino, Alberto C. [1]
Total Authors: 2
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem Engn, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CHEMICAL ENGINEERING RESEARCH & DESIGN; v. 94, p. 456-465, FEB 2015.
Web of Science Citations: 10
Abstract

Pneumatic reactors have been widely employed in various sectors of the chemical industry, especially where it required high heat and mass transfer rates. This study aimed to obtain correlations that allow the prediction of global gas hold-up (epsilon(G)) and volumetric oxygen transfer coefficient (k(L)a), and compare these values, for three models of pneumatic reactors on two scales utilizing viscous Newtonian fluids. Values of k(L)a were obtained using the dynamic pressure-step method, while for EG was used a new proposed of measure. Comparing the three models of reactors studied, it was observed that the mass transfer was superior to draft-tube airlift of 10 L working volume. All correlations showed good fit to the experimental data, and comparisons with correlations from the literature demonstrate the need for further similar studies due to shortage of data available, mainly for airlift reactors operated with viscous Newtonian fluids. The proposed correlations in the present study allow prediction of the main mass transfer parameters and thus contribute significantly for project, operation, and scale-up of bioprocesses involving high density cell cultures of Newtonian characteristic. (C) 2014 The Institution of Chemical Engineers. Published by Elsevier BM. All rights reserved. (AU)

FAPESP's process: 11/23807-1 - Development and evaluation of the operational conditions of bioreactors for production of biotechnological products
Grantee:Alberto Colli Badino Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 12/17756-8 - Evaluation of hydrodynamic conditions, shear and oxygen transfer of different models in pneumatic bioreactors
Grantee:Caroline Eliza Mendes
Support Opportunities: Scholarships in Brazil - Doctorate