| Grant number: | 11/23807-1 |
| Support Opportunities: | Regular Research Grants |
| Start date: | August 01, 2012 |
| End date: | January 31, 2015 |
| Field of knowledge: | Engineering - Chemical Engineering - Industrial Operations and Equipment for Chemical Engineering |
| Principal Investigator: | Alberto Colli Badino Junior |
| Grantee: | Alberto Colli Badino Junior |
| Host Institution: | Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil |
| City of the host institution: | São Carlos |
| Associated researchers: | Cristiane Sanchez Farinas ; Marcel Otavio Cerri |
Abstract
This project proposes to evaluate and compare performance criteria of conventional bioreactor (stirred and aerated tank) operated with different impellers, and non-conventional bioreactors (bubble column and airlift) with different geometries, as well as compare the performances of such equipment in the production processes of clavulanic acid by Streptomyces clavuligerus and cellulases by Aspergillus niger. The research's approach is focused on the bioreactor, i.e., in its model and geometry, on the impeller model (for conventional bioreactor), operating conditions, and operating mode, which define the oxygen mass transfer and shear conditions, morphology and cell growth pattern, the rheology of the broth and the product biosynthesis. In other words, in the present proposal the bioreactor is the main actor, and the applications in the bioproduct production are the case-studies. The proposal will be developed in steps, which will be executed in parallel involving Scientific Initiation, Master's and PhD thesis. They are: A) Evaluation of shear and oxygen transfer conditions in the production of clavulanic acid in conventional bioreactor with different impellers. B) Study of the production and degradation of clavulanic acid in pneumatic bioreactor under low temperatures. C) Evaluation of hydrodynamic conditions, shear and oxygen mass transfer in different pneumatic bioreactors. D) Evaluation of the operating and culture conditions on cellulase production by Aspergillus niger utilizing sugar cane bagasse as inductor. E) Design, construction and experimental analysis and simulation of geometric parameters in hydrodynamics and oxygen mass transfer in pneumatic bioreactors. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |