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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Patterns of seizure control in patients with mesial temporal lobe epilepsy with and without hippocampus sclerosis

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Coan, Ana Carolina [1] ; Campos, Brunno M. [1] ; Bergo, Felipe P. G. [1] ; Kubota, Bruno Y. [1] ; Yasuda, Clarissa L. [1] ; Morita, Marcia E. [1] ; Guerreiro, Carlos A. M. [1] ; Cendes, Fernando [1]
Total Authors: 8
[1] Univ Estadual Campinas, Dept Neurol, Lab Neuroimagem, BR-13081970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Arquivos de Neuro-Psiquiatria; v. 73, n. 2, p. 79-82, FEB 2015.
Web of Science Citations: 8

Objective: Patients with mesial temporal lobe epilepsy (MTLE) may present unstable pattern of seizures. We aimed to evaluate the occurrence of relapse-remitting seizures in MTLE with (MTLE-HS) and without (MTLE-NL) hippocampal sclerosis. Method: We evaluated 172 patients with MTLE-HS (122) or MTLE-NL (50). Relapse-remitting pattern was defined as periods longer than two years of seizure-freedom intercalated with seizure recurrence. ``Infrequent seizures{''} was considered as up to three seizures per year and ``frequent seizures{''} as any period of seizures higher than that. Results: Thirty-seven (30%) MTLE-HS and 18 (36%) MTLE-NL patients had relapse-remitting pattern (X-2, p = 0.470). This was more common in those with infrequent seizures (X-2, p < 0.001). Twelve MTLE-HS and one MTLE-NL patients had prolonged seizure remission between the first and second decade of life (X-2, p = 0.06). Conclusion: Similar proportion of MTLE-HS or MTLE-NL patients present relapse-remitting seizures and this occurs more often in those with infrequent seizures. (AU)

FAPESP's process: 05/56578-4 - Multimodal neuroimaging center for studies in epilepsy
Grantee:Fernando Cendes
Support type: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants