Patterns of seizure control in patients with mesial temporal lobe epilepsy with and without hippocampus sclerosis

Author(s)

Coan, Ana Carolina ^[1] ; Campos, Brunno M. ^[1] ; Bergo, Felipe P. G. ^[1] ; Kubota, Bruno Y. ^[1] ; Yasuda, Clarissa L. ^[1] ; Morita, Marcia E. ^[1] ; Guerreiro, Carlos A. M. ^[1] ; Cendes, Fernando ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Neurol, Lab Neuroimagem, BR-13081970 Campinas, SP - Brazil

• Document type: Journal article
• Source: Arquivos de Neuro-Psiquiatria; v. 73, n. 2, p. 79-82, FEB 2015.
• Web of Science Citations: 8

Abstract

Objective: Patients with mesial temporal lobe epilepsy (MTLE) may present unstable pattern of seizures. We aimed to evaluate the occurrence of relapse-remitting seizures in MTLE with (MTLE-HS) and without (MTLE-NL) hippocampal sclerosis. Method: We evaluated 172 patients with MTLE-HS (122) or MTLE-NL (50). Relapse-remitting pattern was defined as periods longer than two years of seizure-freedom intercalated with seizure recurrence. ``Infrequent seizures{''} was considered as up to three seizures per year and ``frequent seizures{''} as any period of seizures higher than that. Results: Thirty-seven (30%) MTLE-HS and 18 (36%) MTLE-NL patients had relapse-remitting pattern (X-2, p = 0.470). This was more common in those with infrequent seizures (X-2, p < 0.001). Twelve MTLE-HS and one MTLE-NL patients had prolonged seizure remission between the first and second decade of life (X-2, p = 0.06). Conclusion: Similar proportion of MTLE-HS or MTLE-NL patients present relapse-remitting seizures and this occurs more often in those with infrequent seizures. (AU)

• FAPESP's process: 05/56578-4 - Multimodal neuroimaging center for studies in epilepsy
• Grantee: Fernando Cendes
• Support type: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants