Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing

Author(s):Show less -

Corgosinho, Flavia Campos ^{[1, 2]} ; Ackel-D'Elia, Carolina ^{[1, 2]} ; Tufik, Sergio ^{[3, 1]} ; Damaso, Ana Raimunda ^{[4, 1, 2, 5]} ; de Piano, Aline ^{[1, 2]} ; Sanches, Priscila de Lima ^{[1, 2]} ; da Silveira Campos, Raquel Munhoz ^{[1, 2]} ; Silva, Patricia Leao ^{[1, 2]} ; Carnier, June ^{[1, 2]} ; Tock, Lian ^[6] ; Andersen, Monica Levy ^{[3, 1]} ; Moreira, Gustavo Antonio ^{[3, 1]} ; Pradella-Hallinan, Marcia ^{[3, 1]} ; Oyama, Lila Missae ^{[1, 2]} ; de Mello, Marco Tulio ^[7]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Programa Posgrad Nutr, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo UNIFESP, Dept Interdisciplinar Ciencias Saude, Sao Paulo - Brazil

^[6] Weight Sci, Sao Paulo - Brazil

^[7] Univ Fed Minas Gerais, Belo Horizonte, MG - Brazil

• Document type: Journal article
• Source: METABOLIC SYNDROME AND RELATED DISORDERS; v. 13, n. 3, p. 110-118, APR 1 2015.
• Web of Science Citations: 5

Abstract

Obesity is considered a chronic subinflammatory disease and is a risk factor for many diseases such as sleep-disordered breathing (SDB). Although the interaction between obesity and sleep has been explored, not much is known about SDB in the adolescent population. Thus, the aims of this study were, first, to verify the effect of 1 year of interdisciplinary therapy on inflammatory markers in SDB and without SDB and, second, to investigate the influence of SDB on the result of the therapy by comparing these groups. A total of 36 obese adolescents were enrolled; however, only 24 completed the therapy (SDB group, n=12; non-SDB obese group, n=12). Sleep, anthropometric, metabolic, and inflammatory profiles were evaluated at baseline and after the treatment. In both groups, the therapy was able to improve all anthropometric variables. Metabolic parameters such as insulin, homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI) were significantly improved only in non-SDB group. In both groups, the inflammatory state was significantly improved by the reduction in the leptin/adiponectin ratio. After the intervention, both groups no longer presented the hyperleptinemic state, favoring not only the inflammatory state, but also neuroendocrine regulation. Regarding the sleep parameter, the SDB group improved significantly in all respiratory events, and after therapy only four patients remained with SDB. Furthermore, there was an increase in sleep time. The lifestyle intervention was able to improve anthropometric, metabolic, and inflammatory parameters in both groups; however, the presence of SDB impaired better results. The data supported that the inclusion of SDB in the metabolic syndrome because of the link shown between them. (AU)

• FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
• Grantee: Ana Raimunda Dâmaso
• Support type: Regular Research Grants
• FAPESP's process: 06/00684-3 - Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents
• Grantee: Ana Raimunda Dâmaso
• Support type: Regular Research Grants
• FAPESP's process: 13/04136-4 - Analysis of neuroendocrine regulation of balance energy and inflammatory factors in obese adults submitted to bariatric surgery
• Grantee: Ana Raimunda Dâmaso
• Support type: Regular Research Grants