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Analysis of neuroendocrine regulation of balance energy and inflammatory factors in obese adults submitted to bariatric surgery

Grant number: 13/04136-4
Support type:Regular Research Grants
Duration: June 01, 2013 - May 31, 2015
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Ana Raimunda Dâmaso
Grantee:Ana Raimunda Dâmaso
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers: Maria Emilia von Der Heyde ; Solange dos Anjos Martins Cravo Fruet Bettini

Abstract

The prevalence of obesity is steadily growing in many parts of the world in order to reach epidemic proportions. Changes in signaling pathways state of hunger and satiety contribute to the increase in obesity and metabolic syndrome. Currently, the white adipose tissue, also is considered a secretory tissue by producing numerous adipokines involved in a chronic state of inflammation, which may interfere with the neuroendocrine regulation of energy balance difficulting the weight loss process. The bariatric surgery is recommended as the most effective tool in the treatment and control of morbid obesity. The study population will comprise of patients undergoing bariatric surgery - Roux-en-Y gastric bypass - Clinical Hospital of the Federal University of Paraná (UFPR) from March 2013 to April 2014. This is a prospective cohort study with follow up of 6 months. The aim of this study is to assess the effects of weight loss after bariatric surgery associated metabolic changes, the profile of adipokines pro/anti-inflammatory (adiponectin, IL-6, IL-10, CRP, PAI-1, TNF-alpha and resistin) and neuroendocrine regulation of energy balance (leptin, NPY , alpha-MSH, MCH and AgRP), as well as the quality of life in obese adults. (AU)

Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FARIAS, GISELE; NETTO, BARBARA DAL MOLIN; BORITZA, KATIA; BETTINI, SOLANGE CRAVO; VILELA, REGINA MARIA; DAMASO, ANA RAIMUNDA. Impact of Weight Loss on Inflammation State and Endothelial Markers Among Individuals with Extreme Obesity After Gastric Bypass Surgery: a 2-Year Follow-up Study. OBESITY SURGERY, JAN 2020. Web of Science Citations: 0.
FARIAS, GISELE; NETTO, BARBARA DAL MOLIN; BORITZA, KATIA CRISTINA; BETTINI, SOLANGE CRAVO; DAMASO, ANA RAIMUNDA; TEIXEIRA DE FREITAS, ALEXANDRE COUTINHO. Mechanisms of sustained long-term weight loss after RYGB: alpha-MSH is a key factor. Neuropeptides, v. 69, p. 60-65, JUN 2018. Web of Science Citations: 3.
DA SILVEIRA CAMPOS, RAQUEL M.; LANDI MASQUIO, DEBORAH C.; CORGOSINHO, FLVIA CAMPOS; SANCHES, PRISCILA DE LIMA; DE PIANO, ALINE; CARNIER, JUNE; DA SILVA, PATRICIA LEAO; GROTTI CLEMENTE, ANA P.; DE CASTRO FERREIRA VICENTE, SOFIA E.; OYAMA, LILA M.; DA PENHA OLLER DO NASCIMENTO, CLAUDIA M.; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO T.; DAMASO, ANA R. Homeostasis Model Assessment-Adiponectin: the role of different types of physical exercise in obese adolescents. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 57, n. 6, p. 831-838, JUN 2017. Web of Science Citations: 2.
NETTO, BARBARA DAL MOLIN; EARTHMAN, CARRIE P.; FARIAS, GISELE; LANDI MASQUIO, DEBORAH CRISTINA; GROTTI CLEMENTE, ANA PAULA; PEIXOTO, PRISCILLA; BETTINI, SOLANGE CRAVO; VON DER HEYDE, MARIA EMILIA; DAMASO, ANA R. Eating patterns and food choice as determinant of weight loss and improvement of metabolic profile after RYGB. NUTRITION, v. 33, p. 125-131, JAN 2017. Web of Science Citations: 14.
MOLIN NETTO, BARBARA DAL; EARTHMAN, CARRIE P.; BETTINI, SOLANGE CRAVO; GROTTI CLEMENTE, ANA PAULA; LANDI MASQUIO, DEBORAH CRISTINA; FARIAS, GISELE; BORITZA, KATIA; DA SILVA, LARISSA GABRIELLE; VON DER HEYDE, MARIA EMILIA; DAMASO, ANA RAIMUNDA. Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, v. 28, n. 9, p. 1050-1055, SEP 2016. Web of Science Citations: 4.
DUARTE, FERNANDA OLIVEIRA; SENE-FIORESE, MARCELA; DE AQUINO JUNIOR, ANTONIO EDUARDO; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; TOCK, LIAN; GARCIA DE OLIVEIRA DUARTE, ANA CLAUDIA; DAMASO, ANA RAIMUNDA; BAGNATO, VANDERLEI SALVADOR; PARIZOTTO, NIVALDO ANTONIO. Can low-level laser therapy (LLLT) associated with an aerobic plus resistance training change the cardiometabolic risk in obese women? A placebo-controlled clinical trial. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 153, p. 103-110, DEC 2015. Web of Science Citations: 5.
SENE-FIORESE, MARCELA; DUARTE, FERNANDA OLIVEIRA; DE AQUINO JUNIOR, ANTONIO EDUARDO; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; TOCK, LIAN; GARCIA DE OLIVEIRA DUARTE, ANA CLAUDIA; DAMASO, ANA RAIMUNDA; PARIZOTTO, NIVALDO ANTONIO; BAGNATO, VANDERLEI SALVADOR. The Potential of Phototherapy to Reduce Body Fat, Insulin Resistance and ``Metabolic Inflexibility{''} Related to Obesity in Women Undergoing Weight Loss Treatment. Lasers in Surgery and Medicine, v. 47, n. 8, p. 634-642, OCT 2015. Web of Science Citations: 9.
NETTO, BARBARA DAL MOLIN; BETTINI, SOLANGE CRAVO; GROTTI CLEMENTE, ANA PAULA; DE CARVALHO FERREIRA, JOANA PEREIRA; BORITZA, KATIA; SOUZA, SANDY DE FATIMA; VON DER HEYDE, MARIA EMILIA; EARTHMAN, CARRIE P.; DAMASO, ANA R. Roux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesity. OBESITY SURGERY, v. 25, n. 6, p. 1010-1018, JUN 2015. Web of Science Citations: 25.
CORGOSINHO, FLAVIA CAMPOS; ACKEL-D'ELIA, CAROLINA; TUFIK, SERGIO; DAMASO, ANA RAIMUNDA; DE PIANO, ALINE; SANCHES, PRISCILA DE LIMA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; SILVA, PATRICIA LEAO; CARNIER, JUNE; TOCK, LIAN; ANDERSEN, MONICA LEVY; MOREIRA, GUSTAVO ANTONIO; PRADELLA-HALLINAN, MARCIA; OYAMA, LILA MISSAE; DE MELLO, MARCO TULIO. Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing. METABOLIC SYNDROME AND RELATED DISORDERS, v. 13, n. 3, p. 110-118, APR 1 2015. Web of Science Citations: 5.
NETTO, BARBARA DAL MOLIN; LANDI MASQUIO, DEBORAH CRISTINA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; SANCHES, PRISCILA DE LIMA; CORGOSINHO, FLAVIA CAMPOS; TOCK, LIAN; OYAMA, LILA MISSAE; DE MELLO, MARCO TULIO; TUFIK, SERGIO; DAMASO, ANA RAIMUNDA. The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents. NUTRICION HOSPITALARIA, v. 29, n. 2, p. 305-314, FEB 2014. Web of Science Citations: 0.

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