Movement observation-induced modulation of pain perception and motor cortex excitability

Author(s)

Volz, Magdalena Sarah ^{[1, 2, 3]} ; Suarez-Contreras, Vanessa ^{[1, 2]} ; Santos Portilla, Andrea L. ^{[1, 2]} ; Illigens, Ben ^[4] ; Bermpohl, Felix ^[3] ; Fregni, Felipe ^{[1, 2, 4, 5]}

Affiliation

^[1] Harvard Univ, Dept Phys Med & Rehabil, Spaulding Rehabil Hosp, Sch Med, Spaulding Neuromodulat Ctr, Charlestown, MA 02129 - USA

^[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Charlestown, MA 02129 - USA

^[3] Charite Univ Med Berlin, Berlin - Germany

^[4] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Charlestown, MA 02129 - USA

^[5] Univ Sao Paulo, Inst Psychol, NEC, Sao Paulo - Brazil

• Document type: Journal article
• Source: CLINICAL NEUROPHYSIOLOGY; v. 126, n. 6, p. 1204-1211, JUN 2015.
• Web of Science Citations: 3

Abstract

Objective: The observation of movements increases primary motor cortex (M1) excitability. This exploratory study examined the effects of movement observation on pressure pain threshold (PPT) and transcranial magnetic stimulation (TMS)-indexed corticospinal excitability bilaterally. Methods: Thirty healthy right-handed subjects were randomized to a left hand-movement observation task or a control task. Statistical analyses were performed using ANOVA models and t-tests. Results were not corrected for multiple comparisons. Quantitative sensory assessments were measured in both hands, while M1 excitability has only been tested for the right (non-dominant) M1 corresponding to the observed left hand movements. Results: Analysis of pain and cortical silent period (CSP) outcomes demonstrated a significant interaction between task (hand-movement group) versus control group and time (pre-/postintervention). PPT increased in the left hand (moving hand in the task) and declined significantly in the contralateral hand (still hand) in the movement-observation-task-group, whereas PTT in the control group remained unchanged. CSP was significantly shorter in the movement-observation group indicating decreased intracortical inhibition (results uncorrected for multiple comparisons). Conclusions: The observation of hand-movements led to a side-specific reduction in pain perception and a decrease in intracortical inhibition. Significance: These exploratory findings support the notion that M1 is a robust modulator of pain-related neural networks. This effect might be mediated through modulation of the GABAergic system and appears to differ from what is observed in chronic pain. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. (AU)

• FAPESP's process: 12/06519-5 - Effect of transcranial direct current stimulation associated with aerobic exercises on pain of patients with fibromyalgia
• Grantee: Felipe Fregni
• Support Opportunities: Regular Research Grants