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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pilot-scale synthesis and rheological assessment of poly(methyl methacrylate) polymers: Perspectives for medical application

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Author(s):
Linan, Lamia Zuniga [1] ; Nascimento Lima, Nadson M. [1] ; Maciel Filho, Rubens [1] ; Sabino, Marcos A. [2] ; Kozlowski, Mark T. [3] ; Manenti, Flavio [4]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Sch Chem Engn, BR-13083852 Campinas, SP - Brazil
[2] Univ Simon Bolivar, Dept Quim, Grp B5IDA, Caracas 1080A - Venezuela
[3] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 - USA
[4] Politecn Milan, Dipartamento Chim Mat & Ingn Chim, I-20133 Milan - Italy
Total Affiliations: 4
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 51, p. 107-116, JUN 1 2015.
Web of Science Citations: 3
Abstract

This work presents the rheological assessment of poly(methyl methacrylate) (PMMA) polymers synthesized in a dedicated pilot-scale plant. This material is to be used for the construction of scaffolds via Rapid Prototyping (RP). The polymers were prepared to match the physical and biological properties required for medical applications. Differential Scanning Calorimetry (DSC) and Size Exclusion Chromatography (SEC) measurements verified that the synthesized polymers were atactic, amorphous and linear in chains. Rheological properties such as viscosity, storage and loss modulus, beyond the loss factor, and creep and recovery were measured in a plate-plate sensor within the viscoelastic linear region. The results showed the relevant influence of the molecular weight on the viscosity and elasticity of the material, and how, as the molecular weight increases, the viscoelastic properties are getting closer to those of human bone. This article demonstrates that by using the implemented methodology it is possible to synthesize a polymer, with properties comparable to commercially-available PMMA. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 10/16952-2 - Modeling and optimal control by fuzzy logic for processes of production of biomaterials
Grantee:Nádson Murilo Nascimento Lima
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/09631-8 - Study and modeling of poly(methyl methacrylate) production process to obtain artificial bone tissue
Grantee:Rubens Maciel Filho
Support type: Regular Research Grants
FAPESP's process: 09/09092-0 - Study and modeling of the process of production of PMMA for the fabrication of artificial bone cement
Grantee:Lamia Zuniga Linan
Support type: Scholarships in Brazil - Post-Doctorate