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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial and cytotoxic effects of phosphoric acid solution compared to other root canal irrigants

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Author(s):
Prado, Maira [1] ; Nogueira Leal da Silva, Emmanuel Joao [1] ; Duque, Thais Mageste [1] ; Zaia, Alexandre Augusto [1] ; Randi Ferraz, Caio Cezar [1] ; Affonso de Almeida, Jose Flavio [1] ; Figueiredo de Almeida Gomes, Brenda Paula [1]
Total Authors: 7
Affiliation:
[1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Endodont Div, Dept Restorat Dent, Piracicaba, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Applied Oral Science; v. 23, n. 2, p. 158-163, MAR-APR 2015.
Web of Science Citations: 11
Abstract

Phosphoric acid has been suggested as an irrigant due to its effectiveness in removing the smear layer. Objectives : The purpose of this study was to compare the antimicrobial and cytotoxic effects of a 37% phosphoric acid solution to other irrigants commonly used in endodontics. Material and Methods : The substances 37% phosphoric acid, 17% EDTA, 10% citric acid, 2% chlorhexidine (solution and gel), and 5.25% NaOCl were evaluated. The antimicrobial activity was tested against Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Actinomyces meyeri, Parvimonas micra, Porphyromonas gingivalis, and Prevotella nigrescens according to the agar diffusion method. The cytotoxicity of the irrigants was determined by using the MTT assay. Results : Phosphoric acid presented higher antimicrobial activity compared to the other tested irrigants. With regard to the cell viability, this solution showed results similar to those with 5.25% NaOCl and 2% chlorhexidine (gel and solution), whereas 17% EDTA and 10% citric acid showed higher cell viability compared to other irrigants. Conclusion : Phosphoric acid demonstrated higher antimicrobial activity and cytotoxicity similar to that of 5.25% NaOCl and 2% chlorhexidine (gel and solution). (AU)

FAPESP's process: 11/09047-4 - Investigation of microbial diversity from primary endodontic infection by clonal analysis and 16S rRNA sequencing
Grantee:Brenda Paula Figueiredo de Almeida Gomes
Support Opportunities: Regular Research Grants