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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of pretransplant influenza vaccination in hematopoietic SCT: a randomized prospective study

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Author(s):
Ambati, A. [1, 2] ; Boas, L. S. V. [3] ; Ljungman, P. [1, 4] ; Testa, L. [5] ; de Oliveira, J. F. [6] ; Aoun, M. [7] ; Colturato, V. [5] ; Maeurer, M. [7, 2] ; Machado, C. M. [3, 5]
Total Authors: 9
Affiliation:
[1] Karolinska Inst, Dept Med Huddinge, Div Hematol, Stockholm - Sweden
[2] Karolinska Univ Hosp, Ctr Allogene Stem Cell Transplantat CAST, Stockholm - Sweden
[3] Univ Sao Paulo, Inst Trop Med, Virol Lab LIM HCFMUSP 52, BR-05403000 Sao Paulo - Brazil
[4] Karolinska Univ Hosp, Dept Hematol, Stockholm - Sweden
[5] Amaral Carvalho Fdn, Hematopoiet Stem Cell Transplant Program, Jahu - Brazil
[6] Univ Fed Minas Gerais, Clin Hosp Sch Med, Belo Horizonte, MG - Brazil
[7] Karolinska Inst, Dept Lab Med, Div Therapeut Immunol TIM, Stockholm - Sweden
Total Affiliations: 7
Document type: Journal article
Source: BONE MARROW TRANSPLANTATION; v. 50, n. 6, p. 858-864, JUN 2015.
Web of Science Citations: 12
Abstract

Pretransplant influenza vaccination of the donor or allogeneic hematopoietic SCT (HSCT) candidate was evaluated in a randomized study. One hundred and twenty-two HSCT recipients and their donors were assigned to three randomization groups: no pretransplant vaccination (n = 38), donor pretransplant vaccination (n = 44) or recipient pretransplant vaccination (n = 40). Specific IgG was assessed by both hemagglutinin inhibition (HI) and, in 57 patients, by an indirect influenza-specific ELISA at specified times after HSCT. Vaccinated donors had seroprotective HI titers for Ags H1 and H3 (P<0.001) compared with the other groups at the time of donation. The titers against H1 (P = 0.028) and H3 (P<0.001) were highest in the pretransplant recipient vaccination group until day 180 after transplantation. A significant difference was found in the specific Ig levels against pandemic H1N1 at 6 months after SCT (P = 0.02). The mean IgG levels against pandemic H1N1 and generic H1N1 and H3N2 were highest in the pretransplant recipient vaccination group. We conclude that pretransplant recipient vaccination improved the influenza-specific seroprotection rates. (AU)

FAPESP's process: 08/00282-8 - COMPARISON OF ALTERNATIVE SCHEDULES OF INFLUENZA VACCINATION IN HAEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS
Grantee:Clarisse Martins Machado
Support Opportunities: Regular Research Grants