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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An improved method for the regioselective synthesis of highly substituted quinolines from Morita-Baylis-Hillman adducts

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Author(s):
Zeoly, Lucas A. [1] ; Barcelos, Rosimeire C. [1] ; Rodrigues, Jr., Manoel T. [1] ; Gomes, Ralph C. [1] ; Coelho, Fernando [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Lab Synth Nat Prod & Drugs, Inst Chem, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Tetrahedron Letters; v. 56, n. 22, p. 2871-2874, MAY 27 2015.
Web of Science Citations: 5
Abstract

The synthesis of highly substituted quinolines was accomplished through a Heck reaction of substituted iodoanilines with Morita-Baylis-Hillman (MBH) adducts employing Najera N-oxime derived palladacycle as catalyst. The reaction is completely regioselective and gives the products with good to excellent yields (up to 89%) with low catalyst loading and TONs of up to 89. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/24783-1 - Morita-Baylis-Hillman in medicinal chemistry: synthesis and neuroprotective, antimicrobial and antitumoral biological evaluations of new heterocycles, oximes and nitrones
Grantee:Rosimeire Coura Barcelos
Support Opportunities: Scholarships in Brazil - Post-Doctoral